7Z,10Z,13Z,16Z,19Z-Docosapentaenoic acid CAS: 24880-45-3
MF: C22H34O2
MW: 330.50
A fatty acid shown to inhibit platelet aggregation.

7Z,10Z,13Z,16Z,19Z-Docosapentaenoic acid (CAS 24880-45-3)

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Sinonimo: Docosapentaenoic acid
Applicazione: A fatty acid shown to inhibit platelet aggregation
Numero CAS: 24880-45-3
Purezza: ≥98%
Peso molecolare: 330.50
Formula molecolare: C22H34O2
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Docosa-7Z,10Z,13Z,16Z,19Z-pentaenoic Acid (22:5, n-3), also known as DPA, is a fatty acid derived from fish oils that potently inhibits platelet aggregation. DPA has been reported to block the cyclooxygenase pathway and stimulate the lipoxygenase pathway, which results in effective platelet aggregation inhibition. Peripheral blood mononuclear cell research demonstrates that DPA diminishes cyclooxygenase-2 levels intracellularly and inhibits pro-inflammatory prostaglandin E2 production. Studies indicate that the compound plays an important role in the cubic membrane formation of mitochondria found in amoeba Chaos.


Referenze

1. Akiba, S., et al. 2000. Biol. Pharm. Bull. 23: 1293-1297. PMID: 11085354
2. Rissanen, T., et al. 2000. Circulation. 102: 2677-2679. PMID: 11094031
3. Deng, Y., et al. 2009. FASEB J. 23: 2866-2871. PMID: 19406841
4. Nauroth, J.M., et al. 2010. Lipids. 45: 375-384. PMID: 20364438
5. Kaur, G., et al. 2011. Prog. Lipid Res. 50: 28-34. PMID: 20655949

Aspetto :
Oil
Stato fisico :
Liquid
Solubilità :
Soluble in ethanol, hexane, methylene chloride, 0.1M Na2CO3 (1.7 mg/ml), water (1.7 mg/ml) at 25° C, DMSO (~100 mg/ml), and DMF (~100 mg/ml).
CONSERVAZIONE :
Store at -20° C
Indice di rifrazione :
n20D 1.51
IC50 :
Cytochrome P450 19A1: IC50 = 16.8 µM (human)
Valori pK :
pKa: 4.76
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
2
RTECS :
JR1320000
PubChem CID :
5497182
Numero MDL :
MFCD00156103
SMILES :
CC/C=C\\C/C=C\\C/C=C\\C/C=C\\C/C=C\\CCCCCC(=O)O

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