7-Aminoactinomycin D CAS: 7240-37-1
MF: C62H87N13O16
MW: 1270.43
A fluorescent DNA dye for apoptosis and flow cytomtery studies.

7-Aminoactinomycin D (CAS 7240-37-1)

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Nomi alternativi: 7-AAD
Applicazione: 7-Aminoactinomycin D is a fluorescent DNA dye for apoptosis and flow cytomtery studies
Numero CAS: 7240-37-1
Purezza: ≥96%
Peso molecolare: 1270.43
Formula molecolare: C62H87N13O16
Informazioni supplementari: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).

7-Aminoactinomycin D (7-AAD), an analog of the antibiotic actinomycin D (sc-200906), is a fluorescent DNA dye which is useful for quantifying apoptosis. 7-AAD has also been used in studies on cellular necrosis, chromosome analysis and in cell cycle studies. As a fluorescent DNA dye, 7-AAD is able to intercalate DNA via binding to the GC regions. When used in flow cytometery, 7-AAD can be used to discriminate between live cells as well as early and late apoptosis. Additionally, 7-AAD can also be combined with other staining procedures for analysis of intracellular and cell surface antigens enabling multiparametric analysis. When utilizing 7-AAD with flow cytometery, early and late apoptosis can be studied by varying the concentration of 7-AAD. During apoptosis, the cellular plasma membrane is altered progressively, which allows the cell membrane to become permeable to 7-AAD. 7-AAD staining can also be adapted to include staining with other dyes for intracellular and cell surface antigens. 7-Aminoactinomycin D is an inhibitor of DNA Polymerase and RNA Polymerase.


Referenze

1. Sengupta, S.K., et al. 1975. J. Med. Chem. 18: 1175-1180. PMID: 1059773
2. Toba, K., et al. 1992. Cytometry. 13: 60-67. PMID: 1372203
3. Schmid, I., et al. 1992. Cytometry. 13: 204-208. PMID: 1547670
4. Berg, R.J., et al. 1993. Carcinogenesis. 14: 103-106. PMID: 8425255
5. Schmid, I., et al. 1994. J. Immunol. Methods. 170: 145-157. PMID: 8157993
6. Lecoeur, H., et al. 2001. J. Immunol. Methods. 253: 177-187. PMID: 11384679

Stato fisico :
Solid
Solubilità :
Soluble in DMSO (20 mg/ml), ethanol, chloroform (1 mg/ml), and dichloromethane (20 mg/ml).
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
252-253° C
Punto di ebollizione :
~1400.8° C at 760 mmHg (Predicted)
Densità :
~1.4 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.66 (Predicted)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
AU1579000
Trasporto :
UN 3462, Class 6.1, Packing group II
PubChem CID :
Indice Merck :
14: 2800
Numero MDL :
MFCD00077295
Registro Beilstein :
5915844
SMILES :
C[[email protected]@H]1[[email protected]@H](C(=O)N[[email protected]@H](C(=O)N2CCC[[email protected]]2C(=O)N(CC(=O)N([[email protected]](C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=CC(=C(C4=C3N=C5C(=C(C(=O)C(=C5O4)C)N)C(=O)N[[email protected]]6[[email protected]](OC(=O)C(N(C(=O)CN(C(=O)[[email protected]@H]7CCCN7C(=O)[[email protected]](NC6=O)C(C)C)C)C)C(C)C)C)C)N

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7-Aminoactinomycin D (CAS 7240-37-1)  Citazioni prodotti

Vedi quanti altri hanno usato 7-Aminoactinomycin D (CAS 7240-37-1). Clicca sulla voce per laccesso a PubMed .

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PMID: # 26676515  Woo, SM. et al. 2016. Mol Med Rep. 13: 1091-6.

PMID: # 27062556  Blume-Peytavi, U. et al. 2016. J Eur Acad Dermatol Venereol. 30 Suppl 4: 3-56.

PMID: # 25909288  Kim, JH. et al. 2015. Oncotarget. 6: 19528-41.

PMID: # 25486609  Falcón, CR. et al. 2014. PLoS ONE. 9: e114505.

PMID: # 22678910  Martínez, FF. et al. 2012. Eur. J. Immunol. 42: 1573-84.

PMID: # 22848374  Carranza, F. et al. 2012. PLoS ONE. 7: e40356.

PMID: # 20447697  Falcón, C. et al. 2010. Vet. Immunol. Immunopathol. 137: 36-46.

PMID: # 32603375  PLoS Biol. e3000732.

PMID: # 29524201  Mol Biotechnol. 339-349.

Ciatazioni 1 a9 di 9 totali
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