3,3′-Diindolylmethane 3,3′-Diindolylmethane is an antineoplastic agent that activates Chk 2 and cytochrome p450.

3,3′-Diindolylmethane (CAS 1968-05-4)

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3,3′-Diindolylmethane is rated 5.0 out of 5 by 1.
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Nomi alternativi: DIM; Plant Indole; 3,3′-Methylenediindole
Applicazione: 3,3′-Diindolylmethane is an antineoplastic agent that activates Chk 2 and cytochrome p450
Numero CAS: 1968-05-4
Purezza: ≥98%
Peso molecolare: 246.31
Formula molecolare: C17H14N2
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
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3,3′-Diindolylmethane is an anticancer and antineoplastic agent. 3,3′-Diindolylmethane induces apoptosis in human cancer cells. 3,3′-Diindolylmethane is also an activator of CYP (cytochrome P450) and Chk2 (checkpoint kinase 2) as well as a partial agonist of aryl hydrocarbon receptor (Ah Receptor). The compound is a dimer of indole-3-carbinol (sc-202662).


Referenze

Oligomerization of indole-3-carbinol in aqueous acid: K.R. Grose & L.F. Bjeldanes; Chem. Res. Toxicol. 5, 188 (1992) The anticarcinogen 3,3′-diindolylmethane is an inhibitor of cytochrome P-450: D.M. Stresser, et al.; J. Biochem. Toxicol. 10, 191 (1995) 3

Aspetto :
Powder
Stato fisico :
Solid
Solubilità :
Soluble in DMSO (200 mg/ml), ethanol (50 mM), chloroform, and methanol. Insoluble in water.
CONSERVAZIONE :
Store at -20° C
Punto di scioglimento :
167° C
Punto di ebollizione :
~504.2° C at 760 mmHg (Predicted)
Densità :
~1.30 g/cm3 (Predicted)
Indice di rifrazione :
n20D 1.77 (Predicted)
IC50 :
Leishmania donovani: IC50 = 1.25 µM; MCF7: IC50 = 5.5 µM (human); MDA-MB-231: IC50 = 10 µM (human)
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
NM0332000
PubChem CID :
Numero MDL :
MFCD00195766
Registro Beilstein :
223072
SMILES :
C1=CC=C2C(=C1)C(=CN2)CC3=CNC4=CC=CC=C43

Download SDS (MSDS)

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3,3′-Diindolylmethane (CAS 1968-05-4)  Citazioni prodotti

Vedi quanti altri hanno usato 3,3′-Diindolylmethane (CAS 1968-05-4). Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a6 di 6 totali

PMID: # 33947696  Louveau, B.|Resche-Rigon, M.|Lesimple, T.|Da Meda, L.|Pracht, M.|Baroudjian, B.|Delyon, J.|Amini Adle, M.|Dutriaux, C.|Reger de Moura, C.|Sadoux, A.|Jouenne, F.|Ghrieb, Z.|Vilquin, P.|Bouton, D.|Tibi, A.|Huguet, S.|Rezai, K.|Battistella, M.|Mourah, S.|Lebbe, C.| et al. 2021. Clin Cancer Res.

PMID: # 29573889  López-Chillón, MT.|Carazo-Díaz, C.|Prieto-Merino, D.|Zafrilla, P.|Moreno, DA.|Villaño, D.| et al. 2019. Clin Nutr. 38: 745-752.

PMID: # 27430727  Li, H.|Zhao, P.|Xu, Q.|Shan, S.|Hu, C.|Qiu, Z.|Xu, X.| et al. 2016. Sci Rep. 6: 29878.

PMID: # 28801307  Cancer Discov. 7: 1168-1183.

PMID: # 30367535  Protein Sci. 216-227.

PMID: # 33287170  Antioxidants (Basel).

Ciatazioni 1 a6 di 6 totali
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