20-HETE Ethanolamide MF: C22H37NO3
MW: 363.5

20-HETE Ethanolamide

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Peso molecolare: 363.5
Formula molecolare: C22H37NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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This is an endogenous lipid neurotransmitter with cannabinergic activity, binding both the central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. Fatty acid amide hydrolase (FAAH) is the enzyme responsible for the hydrolysis and inactivation of this. Metabolism of AEA by cyclooxygenase-2, leading to formation of prostaglandin ethanolamides, and by lipoxygenases has also been documented as well. This is a potential cytochrome P450 (CYP450) metabolite of AEA, which may be particularly relevant under conditions of FAAH inhibition. Evidence for the formation of 20-HETE ethanolamide in vivo has not been documented.


Referenze

1. Felder, C.C., et al. 1993. Proc. Natl. Acad. Sci. U.S.A. 90: 7656-7660. PMID: 8395053
2. Lambert, D.M. and Fowler, C.J. 2005. J. Med. Chem. 48: 5059-5087. PMID: 16078824
3. Kozak, K.R., et al. 2002. J Biol Chem. 277: 44877-44885. PMID: 12244105
4. Deutsch, D.G., et al. 2002. Prostaglandins Leukot Essent Fatty Acids. 66: 201-210. PMID: 12052036

Formulazione :
A solution in ethanol
Stato fisico :
Liquid
CONSERVAZIONE :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C(CC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCO)CCO

Download SDS (MSDS)

CERTIFICATO DI ANALISI

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