RP105 Activators

Radioprotective 105 (RP105), also known as CD180, is a protein encoded by the MS4A4A gene in humans. It is a member of the Toll-like receptor (TLR) family, a group of proteins that play a crucial role in the innate immune system, the body's first line of defense against pathogens.RP105 is primarily expressed on the surface of B cells, a type of white blood cell involved in adaptive immunity. It has a similar structure to TLR4, another member of the TLR family, but lacks an intracellular TIR domain, which is typically involved in downstream signaling in TLRs.Interestingly, RP105 can form a complex with another protein, MD-1, which is necessary for its proper cell surface expression and function. This RP105/MD-1 complex can modulate B cell responses, with implications for immune reactions and autoimmune diseases.

Studies have shown that RP105 plays an important role in regulating B cell activation and proliferation. Through its interactions with other proteins, RP105 can either promote or inhibit B cell responses, which is crucial for maintaining immune system balance.Alterations in RP105 function have been implicated in various diseases. For instance, its overexpression has been observed in certain types of cancer, including lymphomas and leukemia, suggesting a potential role in tumorigenesis.