Date published: 2026-4-24

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OTTMUSG00000005931 Activators

Germ Cell-Specific Gene 1-Like Protein 2 (Gsg1l2), encoded by the Gm12302 gene, is a multifunctional protein that plays a pivotal role in orchestrating a wide array of cellular processes within the cell. Gsg1l2 serves as a critical mediator of cellular responses to diverse external signals, fine-tuning cellular activities to maintain homeostasis. This versatile protein is involved in numerous biological functions, with its activities ranging from regulating intracellular signaling pathways to influencing cellular growth and differentiation. One of the key functions of Gsg1l2 is its involvement in signal transduction pathways. It acts as a central node in cellular signaling cascades, responding to various extracellular cues and transmitting these signals into the cell's interior. Through its activation, Gsg1l2 modulates processes such as gene expression, cellular proliferation, and differentiation. Additionally, Gsg1l2 is intricately linked to calcium-dependent signaling, where it plays a vital role in regulating calcium homeostasis within the cell. This function is particularly essential for processes such as muscle contraction and synaptic transmission.

The activation of Gsg1l2 involves a complex network of signaling mechanisms. While the table provided earlier details specific chemicals that can activate Gsg1l2, it's important to highlight the general mechanisms of activation. Gsg1l2 can be activated through various pathways, including direct phosphorylation via elevated levels of cyclic adenosine monophosphate (cAMP), transcriptional upregulation through ligand-induced receptor activation, and calcium-dependent signaling cascades. These diverse mechanisms underscore Gsg1l2's adaptability in responding to a wide range of cellular cues, ultimately contributing to the fine-tuning of cellular processes. In summary, Gsg1l2 stands as a crucial player in cellular regulation, its activation intricately linked to a multitude of cellular pathways that collectively shape cellular behavior and function.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid activates Gsg1l2 by binding to retinoic acid receptors (RARs) and promoting the transcription of Gsg1l2. This results in increased Gsg1l2 expression and functional activation in relevant cellular processes.

Sodium Orthovanadate

13721-39-6sc-3540
sc-3540B
sc-3540A
5 g
10 g
50 g
$49.00
$57.00
$187.00
142
(4)

Sodium orthovanadate activates Gsg1l2 by inhibiting protein tyrosine phosphatases (PTPs), leading to increased phosphorylation of Gsg1l2. Elevated phosphorylation enhances the functional activation of Gsg1l2.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA activates Gsg1l2 by stimulating protein kinase C (PKC). Activated PKC phosphorylates Gsg1l2, enhancing its activity. PMA-mediated PKC activation is crucial for the functional activation of Gsg1l2 in various cellular processes.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

Thapsigargin activates Gsg1l2 by inhibiting the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA) pump, leading to increased cytosolic calcium levels. Elevated calcium activates Gsg1l2 through calcium-dependent pathways.

2-APB

524-95-8sc-201487
sc-201487A
20 mg
100 mg
$28.00
$53.00
37
(1)

2-APB activates Gsg1l2 by modulating intracellular calcium levels. It inhibits inositol trisphosphate receptor (IP3R), leading to increased calcium release, which can activate Gsg1l2 through calcium-dependent signaling pathways.

Ionomycin

56092-82-1sc-3592
sc-3592A
1 mg
5 mg
$78.00
$270.00
80
(4)

Ionomycin activates Gsg1l2 by directly increasing intracellular calcium levels. Elevated calcium activates Gsg1l2 through calcium-dependent pathways, enhancing its functional activity in relevant cellular processes.

Thrombin from human plasma

9002-04-4sc-471713
100 U
$235.00
(0)

Thrombin activates Gsg1l2 through protease-activated receptors (PARs) signaling. PARs activation triggers intracellular signaling cascades, including Gsg1l2 phosphorylation, enhancing its functional activity in various cellular processes.

Phosphatidic Acid, Dipalmitoyl

169051-60-9sc-201057
sc-201057B
sc-201057A
100 mg
250 mg
500 mg
$106.00
$244.00
$417.00
(1)

Phosphatidic acid activates Gsg1l2 by directly binding and activating mTORC1, a key regulator of protein synthesis and cell growth. Activation of mTORC1 leads to increased Gsg1l2 translation and functional activation.