MDH2 Activators
MDH2, short for Malate Dehydrogenase 2, is an essential mitochondrial enzyme involved in the citric acid cycle, which is a fundamental metabolic pathway responsible for energy production in cells. Indirect activation or modulation of MDH2 typically involves manipulating the cellular environment and cofactor levels that influence its activity. For instance, MDH2 relies on calcium ions as cofactors for its catalytic function. Consequently, compounds that increase intracellular calcium levels, like calcium ionophores, can indirectly enhance MDH2 activity. Similarly, MDH2 utilizes NAD⁺ (Nicotinamide Adenine Dinucleotide) as a cofactor, and substances that elevate cellular NAD⁺ levels, such as nicotinamide riboside and nicotinamide mononucleotide (NMN), indirectly support MDH2 function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 raises cellular calcium levels, indirectly activating MDH2. MDH2 depends on calcium as a cofactor, and higher calcium levels enhance its function in the citric acid cycle. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide riboside elevates cellular NAD⁺ levels, indirectly supporting MDH2 activity. MDH2 relies on NAD⁺ as a cofactor, and increased NAD⁺ enhances its function. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN, similar to nicotinamide riboside, boosts cellular NAD⁺ levels, indirectly promoting MDH2 activity by providing more of the cofactor it requires. | ||||||