Santa Cruz Biotechnology offers a variety of gene editing products to target growth factors and hormones using the CRISPR/Cas9 system. Ephrins, which act as ligands for Eph receptors, are cell-surface proteins which fall into two categories, ephrin-A and ephrin-B, based on their structure and function. Eph receptors and ephrins exhibit complementary expression in many tissues during embryogenesis indicating that bidirectional activation of Eph receptors and ephrin-B proteins may occur at expression domain interfaces. Mouse, rat, human and Xenopus laevis ephrin-B1 are phosphorylated on Tyr 317 in vivo, which may be induced by a receptor tyrosine kinase. A total of three members of the transforming growth factor beta (TGFβ) family, TGFβ1, TGFβ2 and TGFβ3, have been identified in mammals. To knockdown expression of growth factors and hormones, Santa Cruz Biotechnology offers target-specific CRISPR/Cas9 Knockout (KO) Plasmids and CRISPR Double Nickase Plasmids.To activate transcription of growth factor and hormone genes, Santa Cruz Biotechnology offers target-specific CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems.
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