calsequestrin 2 Activators
Calsequestrin 2 activators, as listed, are primarily chemicals that indirectly affect CASQ2 activity by influencing calcium dynamics and sarcoplasmic reticulum function. CASQ2 is integral to calcium storage within the sarcoplasmic reticulum and plays a key role in regulating calcium release during muscle contraction. The chemicals mentioned, such as ryanodine receptor modulators (Ryanodine, Caffeine, Dantrolene), SERCA inhibitors (Thapsigargin, Cyclopiazonic Acid), and calcium channel blockers (Amlodipine, Verapamil, Nifedipine), act on different aspects of calcium handling, potentially impacting the function of CASQ2.
These activators are significant in understanding the complex mechanisms of calcium regulation in muscle cells, particularly in cardiac muscle where CASQ2 plays a prominent role. For instance, modulating ryanodine receptors can influence the calcium release that CASQ2 helps regulate. Similarly, altering the activity of SERCA or calcium channels can impact the calcium storage and release dynamics, thereby indirectly affecting CASQ2 function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine interacts with ryanodine receptors, potentially modifying calcium release and indirectly affecting CASQ2 function in calcium storage. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine sensitizes ryanodine receptors, which could alter sarcoplasmic reticulum calcium release and influence CASQ2 activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), potentially altering calcium handling and CASQ2 activity. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic acid is another SERCA inhibitor, which could modify calcium storage dynamics involving CASQ2. | ||||||
Amlodipine | 88150-42-9 | sc-200195 sc-200195A | 100 mg 1 g | $74.00 $166.00 | 2 | |
Amlodipine, a calcium channel blocker, might indirectly influence calcium handling and CASQ2 function in muscle cells. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol Hydrochloride activates beta-adrenergic receptors, potentially influencing calcium handling and CASQ2 activity. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
12β-Hydroxydigitoxin inhibits the Na+/K+ ATPase, indirectly affecting calcium dynamics and potentially influencing CASQ2 activity. | ||||||