cadherin-19 Activators
Cadherin-19 activators belong to a class of compounds that are designed to modulate the function of the protein cadherin-19, a type of cell adhesion molecule that belongs to the cadherin superfamily. Cadherins are calcium-dependent transmembrane proteins that play a crucial role in cell-cell adhesion, mediating intercellular connections through homophilic interactions (binding to the same type of cadherin on adjacent cells). They are integral to the structure and function of tissues, contributing to the maintenance of tissue architecture and the signaling pathways that govern cellular processes such as proliferation, differentiation, and migration.
Activators targeting cadherin-19 can work through various mechanisms to enhance the protein's adhesive functions. Direct activators may bind to cadherin-19 and induce a conformational change that increases its affinity for binding to identical cadherins on neighboring cells, thereby strengthening cell-cell adhesion. They may also promote the clustering of cadherin-19 at the cell surface, which is important for the formation of adherens junctions, specialized structures that are essential for the maintenance of tissue integrity. Indirect activators of cadherin-19 might influence the protein's function through modifications in the cellular environment or intracellular signaling pathways that affect the expression, localization, or stability of cadherin-19. These could include pathways that regulate the cytoplasmic partners of cadherin-19, such as catenins, which link cadherins to the actin cytoskeleton and are vital for the transmission of signals from the extracellular environment to the cell's interior.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin enhances the activity of adenylate cyclase, leading to an increase in cyclic AMP (cAMP) levels. Cadherin-19, as a calcium-dependent cell adhesion molecule, can be influenced by elevated cAMP levels, which can promote the phosphorylation of proteins involved in the stabilization of cadherin-mediated cell adhesion. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $156.00 $612.00 | 27 | |
Calmidazolium chloride is a calmodulin antagonist that can increase the intracellular calcium concentration. As a calcium-dependent cell adhesion protein, Cadherin-19 can be activated by this increase in calcium concentration, thereby enhancing its function in cell adhesion. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $59.00 $173.00 | 15 | |
Nifedipine is a calcium channel blocker that inhibits the influx of calcium ions through L-type calcium channels. This can stimulate a compensatory increase in intracellular calcium concentration, which can activate Cadherin-19, enhancing its cell adhesion function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium concentration. This increase can activate Cadherin-19, enhancing its cell adhesion function. | ||||||
Sodium Orthovanadate | 13721-39-6 | sc-3540 sc-3540B sc-3540A | 5 g 10 g 50 g | $49.00 $57.00 $187.00 | 142 | |
Sodium orthovanadate is a potent inhibitor of protein tyrosine phosphatases. By inhibiting these phosphatases, it can enhance the phosphorylation of proteins involved in Cadherin-19-mediated cell adhesion, thereby enhancing Cadherin-19 function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, and by inhibiting specific kinases, it can enhance the phosphorylation of proteins involved in Cadherin-19-mediated cell adhesion, thereby enhancing Cadherin-19 function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid inhibits protein phosphatases, leading to an increase in the overall level of protein phosphorylation. This can enhance the phosphorylation of proteins involved in Cadherin-19-mediated cell adhesion, thereby enhancing Cadherin-19 function. | ||||||
Calcium chloride anhydrous | 10043-52-4 | sc-207392 sc-207392A | 100 g 500 g | $66.00 $262.00 | 1 | |
Calcium chloride increases the concentration of calcium ions in the cellular environment. As Cadherin-19 is activated by calcium, this chemical directly enhances the function of Cadherin-19 by providing additional calcium ions necessary for its activation. | ||||||