ADAM22 Activators
ADAM22, a member of the ADAM (A Disintegrin And Metalloproteinase) family of transmembrane proteins, plays a crucial role in various cellular processes, including cell adhesion, migration, and proteolysis. ADAM22 is known for its involvement in modulating synaptic transmission in the nervous system, particularly in the context of excitatory synapses. Recent research has focused on identifying chemical compounds that can selectively activate ADAM22, with the aim of elucidating its physiological functions and exploring potential implications for cellular signaling. The chemical class referred to as ADAM22 Activators encompasses a group of compounds that exhibit the ability to modulate the activity of ADAM22, either by directly binding to the protein or by influencing its regulatory pathways.
Structurally diverse, ADAM22 Activators interact with specific binding sites on the ADAM22 protein, inducing conformational changes that impact its function. These compounds may act as allosteric modulators or agonists, triggering downstream signaling cascades that regulate synaptic plasticity and neurotransmission. Understanding the structural and biochemical properties of ADAM22 Activators provides valuable insights into the molecular mechanisms governing neuronal communication and synaptic function. Ongoing research aims to characterize the binding kinetics, selectivity, and downstream effects of these activators, shedding light on the intricate interplay of molecular events orchestrated by ADAM22 in the context of neural processes. The exploration of ADAM22 Activators thus represents a critical avenue in unraveling the complexities of cellular communication within the nervous system and holds promise for advancing our comprehension of fundamental neurobiological phenomena.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
As a potent antioxidant, Epigallocatechin gallate (EGCG) is known to modulate neuronal signaling pathways. EGCG can enhance synaptic plasticity, which may in turn upregulate the expression of ADAM22 on the neuronal surface, augmenting its role in the modulation of cell-matrix interactions and synaptic function. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
Heparin, a highly sulfated glycosaminoglycan, can bind to and modulate extracellular matrix proteins, potentially increasing the substrate availability for ADAM22, which could enhance its proteolytic activity and its role in cell adhesion and migration. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine, a polyamine involved in cellular signaling, can modulate ion channel function and cellular adhesion. Its presence could stabilize membrane microdomains, which may enhance the functional activity of ADAM22 by increasing its accessibility to its substrates and interaction partners. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
As an antioxidant, N-Acetylcysteine (NAC) provides cysteine, which can influence the redox state of the cell. A more reducing environment can enhance the activity of ADAM22 by maintaining its structure, which is critical for its interaction with integrins and other cell adhesion molecules. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium sulfate can influence NMDA receptor activity, and ADAM22 has been implicated in modulating synaptic functions. Enhancing NMDA receptor activity may indirectly increase the functional activity of ADAM22 by promoting synaptic plasticity where ADAM22 is involved. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic acid (TUDCA) is a bile acid with neuroprotective properties. By stabilizing cellular membranes and maintaining cellular signaling integrity, TUDCA can enhance the functional activity of ADAM22, which is involved in the regulation of synaptic stability. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $119.00 $364.00 $947.00 | 17 | |
Concanavalin A is a lectin that can bind to and cluster glycoproteins, potentially enhancing ADAM22-mediated cell-cell interactions by promoting the clustering of its substrates, which can enhance its functional activity in synaptic signaling. | ||||||
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol is essential for maintaining membrane fluidity and microdomain formation. By influencing these membrane characteristics, cholesterol can indirectly enhance the functional activity of ADAM22 by optimizing its localization and interactions within the lipid rafts. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is involved in redox reactions and cellular signaling. Increased levels of NAD+ can enhance metabolic functions and cellular signaling, potentially upregulating ADAM22 function due to its role in synaptic signaling and plasticity. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a cofactor for many enzymes and is also known to play a role in synaptic transmission and plasticity. Zinc sulfate supplementation can enhance the proteolytic activity of metalloproteases such as ADAM22, indirectly enhancing its functional activity in the synaptic cleft. | ||||||