Anticorps Whirlin (A-12): sc-271508
- L'Anticorps Whirlin (A-12) est un monoclonal de souris IgG2b (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre les acides aminés 608-907 situés au niveau C-terminus de Whirlin d'origine human
- recommandé pour la détection de Whirlin isoforms 1, 3 and 4 d'origine mouse, rat et human par WB, IP, IF et ELISA
- 2b BP-HRP">m-IgG2b BP-HRP et m-IgGκ BP-HRP sont les réactifs de détection secondaire préférés pour l'anticorps Whirlin (A-12) pour les applications WB. Ces réactifs sont désormais proposés en lots avec l'anticorps Whirlin (A-12)(voir les informations relatives à la commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
VOIR ÉGALEMENT...
Whirlin is a cytoplasmic PDZ domain-containing protein that plays a role in elongation and maintenance of stereocilia, mechanosensory organelles located in hair cells of the inner ear. Whirlin co-localizes with actin filaments and is primarily detected in cochlear hair cells. It is connected to the dynamic Usher protein interactome and has a pleiotropic function in both the retina and the inner ear. Myosin XVa is a motor protein that accociates with the second and third PDZ domain of Whirlin through its C-terminal PDZ-ligand. Myosin XVa then delivers Whirlin to the tips of stereocilia, which are subsequently elongated. p55 also interacts with Whirlin, and mutations in DFNB31, the Whirlin gene, lead to an early ablation of p55 labeling of stereocilia, which may cause recessive hearing loss in rats and humans.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps Whirlin (A-12) | sc-271508 | 200 µg/ml | $316.00 | |||
Whirlin (A-12): m-IgGκ BP-HRP Kit | sc-534982 | 200 µg Ab; 40 µg BP | $354.00 | |||
Whirlin (A-12): m-IgG2b BP-HRP Kit | sc-549326 | 200 µg Ab; 10 µg BP | $354.00 |