TLCK hydrochloride CAS: 4238-41-9
MF: C14H21ClN2O3S•HCl
MW: 369.3

TLCK hydrochloride (CAS 4238-41-9)

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Noms alternatifs: TLCK hydrochloride is also known as Tosyllysine Chloromethyl Ketone Hydrochloride.
Application: TLCK hydrochloride is an active site-directed agent and irreversible inhibitor of trypsin-like serine proteases.
Numéro CAS: 4238-41-9
Pureté: ≥95%
Masse Moléculaire: 369.3
Formule Moléculaire: C14H21ClN2O3S•HCl
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
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TLCK hydrochloride, or Tosyllysine Chloromethyl Ketone hydrochloride, is an active site-directed agent that irreversibly inhibits trypsin-like serine proteases such as granzyme D and tryptase. Cysteine proteinases and other enzymes may be inhibited by TLCK hydrochloride through non-selectively acting with thiol groups. To prevent proteolytic degradation, TLCK hydrochloride may be employed in protein purification protocols. TLCK hydrochloride selectively inactivates clostripain obtained from C. histolyticum. TLCK hydrochloride also inhibits other proteases including plasmin, thrombin, and papain and some kinases including PKC. TLCK hydrochloride inhibits LPS-induced expression of COX-2 in macrophages.


Références

1. Urban, M.K., et al. 1979. Biochemistry. 18: 3952-3960. PMID: 486404

2. Jenne, D.E. and Tschopp, J. 1988. Immunol. Rev. 103: 53-71. PMID: 3292396

3. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215: 721-729. PMID: 7488014

4. Abate, A., et al. 1998. Prostaglandins Other Lipid Mediat. 56: 277-290. PMID: 9990673

État Physique :
Solid
Séquence :
Nα-Tosyl-Lys-chloromethylketone⋅HCl
Solubilité :
Soluble in methanol (50 mg/ml), DMSO (5 mM), water,Stock solutions at concentrations up to 10 mM can be prepared in aqueous buffers with a pH of 6.0 or lower. TLCK is very unstable in buffers with a pH higher then 6 and will decompose rapidly. PBS(pH 7.2) (~5 mg/ml), and DMF (~20 mg/ml).
STOCKAGE :
Store at -20° C
Point de fusion :
160-161° C
Point d'Ébullition :
509.8° C at 760 mmHg
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
WGK Allemagne :
3
RTECS :
XT5160000
PubChem CID :
Numéro MDL :
MFCD00065395
Numéro CE :
224-266-4
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)N[[email protected]@H](CCCCN)C(=O)CCl.Cl

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TLCK hydrochloride (CAS 4238-41-9)  Références bibliographiques

Consultez les publications faisant référence à l' utilisation de TLCK hydrochloride (CAS 4238-41-9). Cliquez sur le lien pour afficher lentrée PubMed .

Citations 1 à 2 sur un total de 2

PMID: # 24973403  Moon, HG. et al. 2014. American journal of physiology. Lung cellular and molecular physiology. 307: L326-37.

PMID: # 31296534  J. Cell Biol. 218: 2782-2796.

Citations 1 à 2 sur un total de 2
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