Sodium Butyrate CAS: 156-54-7
MF: C4H7O2Na
MW: 110.09

Sodium Butyrate (CAS 156-54-7)

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Noms alternatifs: Sodium Butyrate also known as Butyric acid sodium salt; Butanoicacidsodiumsalt butyratesodium; sodiumpropanecarboxylate
Application: Sodium Butyrate is an HDAC inhibitor, apoptosis inducer and can induce differentiation and gene expression and also prevent cell proliferation
Numéro CAS: 156-54-7
Pureté: ≥98%
Masse Moléculaire: 110.09
Formule Moléculaire: C4H7O2Na
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
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Sodium Butyrate has been reported to cause hyperacetylation of histones due to its role as a histone deacetylase (HDAC) inhibitor (IC50 values are 0.3, 0.4, 0.3, mM for HDAC1, 2 and 7 respectively). Sodium Butyrate has been shown to cause induction of differentiation and gene expression and also prevent cell proliferation. Mechanistic studies suggest that the action of Sodium Butyrate is often mediated through Sp1/Sp3-associated HDAC activity which leads to transcriptional activation of the p21 gene. Additionally Sodium Butyrate demonstrates the ability to downregulate numerous genes associated with cytokine signaling, specifically, the IFN-γ (interferon γ) pathway.


Références

1. Sealy, L., et al., 1978. The effect of sodium butyrate on histone modification. Cell. 14(1): 115-21. PMID: 667928

2. Davie, James R., et al., 2003. Inhibition of histone deacetylase activity by butyrate. The Journal of nutrition. 133(7 Suppl): 2485S-2493S. PMID: 12840228

3. Joseph, Jeena., et al., 2004. Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB. Oncogene. 23(37): 6304-15. PMID: 15318170

4. Sekhavat, Anoushe., et al., 2007. Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. Biochemistry and cell biology = Biochimie et biologie cellulaire. 85(6): 751-8. PMID: 18059533

État Physique :
Solid
Solubilité :
Soluble in water (0.1 g/ml), DMSO (<1 mg/ml), ethanol (~5 mg/ml), and PBS pH7.2 (~10 mg/ml). Insoluble in ether.
STOCKAGE :
Store at -20° C
Point de fusion :
250-253° C (lit.)
IC50 :
Histone deacetylase 7: IC50 = 140 µM (human); Histone deacetylase 8: IC50 = 140 µM (human); Histone deacetylase 1: IC50 = 140 µM (human)
Ki Data :
Carbonic anhydrase: Ki= 26.9 µM (Candida albicans ); Carbonic anhydrase I: Ki= 511 µM (human)
Valeurs pK :
pKa: 4.82
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
WGK Allemagne :
1
RTECS :
ET6400000
PubChem CID :
Numéro MDL :
MFCD00002816
Numéro CE :
205-857-6
Registre Beilstein :
3629439
SMILES :
CCCC(=O)[O-].[Na+]

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Sodium Butyrate (CAS 156-54-7)  Références bibliographiques

Consultez les publications faisant référence à l' utilisation de Sodium Butyrate (CAS 156-54-7). Cliquez sur le lien pour afficher lentrée PubMed .

Citations 1 à 10 sur un total de 13

PMID: # 29235036  Ho, CF.|Bon, CP.|Ng, YK.|Herr, DR.|Wu, JS.|Lin, TN.|Ong, WY.| et al. 2018. Neurochem. Res. 43: 540-555.

PMID: # 25342559  Yang, Y. et al. 2014. Cell Res. 24: 1342-53.

PMID: # 24682235  Simiczyjew, A.|Mazur, AJ.|Popow-Woźniak, A.|Malicka-Błaszkiewicz, M.|Nowak, D.| et al. 2014. Histochem Cell Biol. 142: 307-22.

PMID: # 17967882  Pesavento, JJ. et al. 2008. Mol. Cell. Biol. 28: 468-486.

PMID: # 17881451  Neumann, DM. et al. 2007. J. Virol. 81: 13248-13253.

PMID: # 16699007  Lu, F. et al. 2006. J. Virol. 80: 5273-5282.

PMID: # 12654818  Scaife, H. et al. 2003. Infect. Immun. 71: 1995-2001.

PMID: # 11884567  Chiou, CJ. et al. 2002. J. Virol. 76: 3421-3439.

PMID: # 10639456  Gerçeker, AA. et al. 2000. Infect. Immun. 68: 861-870.

PMID: # 9971760  Gasmi, M. et al. 1999. J. Virol. 73: 1828-1834.

Citations 1 à 10 sur un total de 13
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