Anticorps RUNDC3A (E-2): sc-377090
- L'Anticorps RUNDC3A (E-2) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 200 µg/ml
- dirigé contre les acides aminés 276-340 dans une région interne de RUNDC3A d'origine human
- recommandé pour la détection de RUNDC3A d'origine mouse, rat et human par WB, IP, IF, IHC(P) et ELISA
- m-IgG1 BP-HRP est le réactif secondaire recommandé pour la détection de l'anticorps RUNDC3A (E-2) pour des applications de WB and IHC(P). Ce réactif est maintenant proposé en kit avec l'anticorps RUNDC3A (E-2) (voir Informations pour la commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
RUNDC3A (RUN domain containing 3A), also known as RPIP-8 (Rap2-interacting protein 8) or RAP2IP, is a 446 amino acid protein that is thought to act as an effector protein of RAP2A in neuronal cells. A member of the RUNDC3 family, RUNDC3A contains one RUN domain and undergoes alternative splicing events to produce four isoforms. RUNDC3A is expressed in testis, brain, kidney and liver, and is encoded by a gene that maps to human chromosome 17q21.31. Chromosome 17 comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, though specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps RUNDC3A (E-2) | sc-377090 | 200 µg/ml | $316.00 | |||
RUNDC3A (E-2): m-IgG1 BP-HRP Kit | sc-542705 | 200 µg Ab; 20 µg BP | $354.00 |