PluriSln 1 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1). It is useful for eliminating undifferentiated human pluripotent stem cells (hPSCs) from culture by selectively inducing apoptosis in these cells. Additionally, pluriSln 1 induces endoplasmic reticulum stress, reduces protein synthesis, and prevents teratoma formation in immunocompromised mice models.
1. Ben-David, Uri., et al., 2013. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell stem cell. 12(2): 167-79. PMID: 23318055