Pifithrin-mu CAS: 64984-31-2
MF: C8H7NO2S
MW: 181.2
An inhibitor of p53 activity and HSP 70 activity.

Pifithrin-μ (CAS 64984-31-2)

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Noms alternatifs: 2-Phenylacetylenesulfonamide; NSC 303580
Application: Pifithrin-µ is an inhibitor of p53 activity and HSP 70 activity
Numéro CAS: 64984-31-2
Pureté: ≥98%
Masse Moléculaire: 181.2
Formule Moléculaire: C8H7NO2S
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
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Pifithrin-μ is a cell-permeable sulfonamide inhibitor of p53 binding and an anti-apoptotic. Direct inhibition of p53 binding to mitochondria as well as to Bcl-xL and Bcl-2 proteins by Pifithrin-μ has been observed. Pifithrin-μ selectively inhibits p53 translocation to mitochondria without affecting the transactivation function of p53. Pifithrin-μ has been shown to reduce γ-radiation induced cell death in vitro. Unlike pifithrin-α (sc-45050), pifithrin-μ targets only the mitochondrial branch of the p53 pathway without affecting the important transcriptional functions of p53. Pifithrin-μ selectively inhibits HSP 70 (heat shock protein 70) activity.


Références

1. Strom, Evguenia., et al., 2006. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nature chemical biology. 2(9): 474-9. PMID: 16862141
2. Vaseva, Angelina V., et al., 2009. The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells. Cell cycle (Georgetown, Tex.). 8(11): 1711-9. PMID: 19411846
3. Subramanian, S V., et al., 2009. Do burdens of underweight and overweight coexist among lower socioeconomic groups in India? The American journal of clinical nutrition. 90(2): 369-76. PMID: 19515733
4. Drakos, E., et al., 2009. The therapeutic potential of p53 reactivation by nutlin-3a in ALK+ anaplastic large cell lymphoma with wild-type or mutated p53. Leukemia. 23(12): 2290-9. PMID: 19741726
5. Hagn, Franz., et al., 2010. BclxL changes conformation upon binding to wild-type but not mutant p53 DNA binding domain. The Journal of biological chemistry. 285(5): 3439-50. PMID: 19955567
6. Xu, Xia., et al., . Enhancement of cell recovery for dissociated human embryonic stem cells after cryopreservation. Biotechnology progress. 26(3): 781-8. PMID: 20014103

État Physique :
Solid
Solubilité :
Soluble in DMSO (>10 mg/mL), water (<2 mg/mL), and ethanol (100 mM).
STOCKAGE :
Store at 4° C
Point de fusion :
136-138° C
Point d'Ébullition :
351.70° C at 760 mmHg (Predicted)
Densité :
1.40 g/cm3 (Predicted)
Indice de Réfraction :
n20D 1.63 (Predicted)
Valeurs pK :
pKa: 7.96 (Predicted)
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
WGK Allemagne :
3
PubChem CID :
Numéro MDL :
MFCD00181531
SMILES :
C1=CC=C(C=C1)C#CS(=O)(=O)N

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Pifithrin-mu (CAS 64984-31-2)  Références bibliographiques

Consultez les publications faisant référence à l' utilisation de Pifithrin-mu (CAS 64984-31-2). Cliquez sur le lien pour afficher lentrée PubMed .

Citations 1 à 4 sur un total de 4

PMID: # 26884717  Yu, W. et al. 2016. Int. J. Biol. Sci. 12: 198-209.

PMID: # 26703711  Claus, C. et al. 2015. Viruses. 7: 6108-26.

PMID: # 24244355  Sekihara, K. et al. 2013. PLoS ONE. 8: e78772.

PMID: # 19955567  Hagn, F. et al. 2010. J. Biol. Chem. 285: 3439-3450.

Citations 1 à 4 sur un total de 4
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