Physostigmine hemisulfate is a derivative of Physostigmine (sc-202764). Physostigmine hemisulfate is an alkaloid originally derived from the Calabar bean Physostigma venenosum. Physostigmine hemisulfate is noted to act as a potent and reversible inhibitor of cholinesterase. Physostigmine hemisulfate is also reported to form a slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE). Physostigmine hemisulfate has been used as a positive control in a study investigating acetylcholinesterase inhibitors for potential antihelminthic drug targets. Additionally, this parasympathomimetic compound is reported to cross the blood-brain barrier in a research study.
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