Physostigmine hemisulfate CAS: 64-47-1
MF: (C15H21N3O2)2•H2SO4
MW: 648.77

Physostigmine hemisulfate (CAS 64-47-1)

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Noms alternatifs: Physostigmine hemisulfate is also known as Eserine sulfate.
Application: Physostigmine hemisulfate is a useful analogue of Physostigmine that acts as a potent and reversible inhibitor of cholinesterase.
Numéro CAS: 64-47-1
Masse Moléculaire: 648.77
Formule Moléculaire: (C15H21N3O2)2•H2SO4
Information supplémentaire: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
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Physostigmine hemisulfate is a derivative of Physostigmine (sc-202764). Physostigmine hemisulfate is an alkaloid originally derived from the Calabar bean Physostigma venenosum. Physostigmine hemisulfate is noted to act as a potent and reversible inhibitor of cholinesterase. Physostigmine hemisulfate is also reported to form a slowly degrading carbamylated enzyme complex with acetylcholinesterase (AChE). Physostigmine hemisulfate has been used as a positive control in a study investigating acetylcholinesterase inhibitors for potential antihelminthic drug targets. Additionally, this parasympathomimetic compound is reported to cross the blood-brain barrier in a research study.


Références

1. Tamaddonfard, E. and Hamzeh-Gooshchi, N. 2010. Pharmacol Rep. 62: 858-863. PMID: 21098868

2. Valli, M., et al. 2011. Curr Med Chem. [Epub ahead of print]. PMID: 21728957

3. Kalogiannis, M., et al. 2011. PLoS ONE. 6: e18697. PMID: 21533254

État Physique :
Solid
Solubilité :
Soluble in water (100 mM).
STOCKAGE :
Desiccate at 4° C
Indice de Réfraction :
n20D 1.57 (Predicted)
IC50 :
Acetylcholinesterase: IC50 = 0.68 nM (mouse); Acetylcholinesterase: IC50 = 1 nM (rat); Butyrylcholinesterase: IC50 = 7.8 nM (rat); BChE: IC50 = 15 nM (human); AChE: IC50 = 0.008 ug/ml (human)
Ki Data :
Acetylcholinesterase: Ki= 34 nM (Electrophorus electricus); Cholinesterase: Ki= 41 nM (Equus caballus); BChE: Ki= 5 µM (human)
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
WGK Allemagne :
3
RTECS :
UY8585000
PubChem CID :
Numéro MDL :
MFCD06795853
Numéro CE :
200-585-4
Registre Beilstein :
3828413
SMILES :
C[[email protected]@]12CCN([[email protected]@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C.C[[email protected]@]12CCN([[email protected]@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C.OS(=O)(=O)O

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