Perazine Dihydrochloride (CAS 5317-37-3)
ACCÈS RAPIDE AUX LIENS
Perazine is a human cytochrome P450 isoenzyme 1A2 (CYP1A2) inhibitor. Dixon analysis in human liver microsomes and Supersomes CYP1A2 showed potent inhibition of caffeine 3-N-demethylation and 1-N-demethylation, as well as moderate inhibition of caffeine 7-N-demethylation. Attenuation of C-8-hydroxylation was seen in Supersomes CYP1A2, however, weak inhibition of caffeine C-8-hydroxylation was found.
Références
1. Franke, U., et al., 1999. Ionization constants and distribution coefficients of phenothiazines and calcium channel antagonists determined by a pH-metric method and correlation with calculated partition coefficients. Journal of pharmaceutical sciences. 88(1): 89-95. PMID: 9874707
2. Hashem, H., et al., 2005. The effect of the process variables on the HPLC separation of tricyclic neuroleptics on a calixarene-bonded stationary phase. Die Pharmazie. 60(3): 186-92. PMID: 15801670
3. Wójcikowski, Jacek., et al., . Perazine at therapeutic drug concentrations inhibits human cytochrome P450 isoenzyme 1A2 (CYP1A2) and caffeine metabolism--an in vitro study. Pharmacological reports : PR. 61(5): 851-8. PMID: 19904008
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