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NAPRT (nicotinate phosphoribosyltransferase), also known as FHA-HIT-interacting protein or nicotinate phosphoribosyltransferase domain-containing protein 1, is a 538 amino acid member of the NAPRTase protein family. Localized to the cytoplasm, NAPRT is involved in the biosynthesis of the cofactor NAD(+). NAPRT catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN). This conversion is essential to increase cellular NAD levels, which prevents oxidative stress of the cells. NAPRT is expressed as three isoforms produced by alternative splicing events. The gene that encodes NAPRT maps to human chromosome 8, which makes up nearly 146 million bases and encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and are typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps NAPRT (D-8) | sc-398746 | 200 µg/ml | $316.00 | |||
NAPRT (D-8): m-IgG Fc BP-HRP Kit | sc-538515 | 200 µg Ab; 10 µg BP | $354.00 | |||
NAPRT (D-8): m-IgGκ BP-HRP Kit | sc-536141 | 200 µg Ab; 40 µg BP | $354.00 | |||
NAPRT (D-8): m-IgG1 BP-HRP Kit | sc-545744 | 200 µg Ab; 20 µg BP | $354.00 | |||
NAPRT (D-8) peptide neutralisant | sc-398746 P | 100 µg/0.5 ml | $68.00 |