MCP-1-4/eotaxin Antibody (B-2) is a high quality monoclonal MCP-1-4/eotaxin antibody (also designated CCL2 (MCP-1) antibody, CCL8 (MCP-2) antibody, CCL7 (MCP-3) antibody, CCL13 (MCP-4) antibody, CCL11 (eotaxin) antibody, or C-C motif chemokine ligand antibody) suitable for the detection of the MCP-1-4/eotaxin protein of human origin. MCP-1-4/eotaxin Antibody (B-2) is available as both the non-conjugated anti-MCP-1-4/eotaxin antibody form, as well as multiple conjugated forms of anti-MCP-1-4/eotaxin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Eotaxin and the monocyte chemotactic proteins, MCP-1–5, form a subfamily of the C-C (or β) chemokines, which are characterized by a set of conserved adjacent cysteines. MCPs are produced by a variety of cells, including T lymphocytes, subsequent to their activation with cytokines such as IL-1, TNFα and IFN-γ. In vitro studies have shown that the MCP isoforms exhibit their chemotactic effects on different subpopulations of lymphocytes. MCP-1 is a potent basophil activator but does not affect eosinophils. MCP-1 levels are increased during infection and inflammation, which are both characterized by leukocyte infiltration. Two MCP-1 receptors, which differ in their carboxy-termini, have been identified. MCP-2 stimulates both eosinophils and basophils, while eotaxin serves as a potent chemo-attractant for eosinophils. MCP-3 has been shown to have the broadest range of influence, activating monocytes, dendritic cells, lymphocytes, NK cells, eosinophils, basophils and neutrophils. MCP-4 signals through CCR-2 and -3 and is a potent chemoattractant for monocytes, eosinophils and basophils induced in allergic and nonallergic inflammation.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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