Kanamycin B sulfate CAS: 29701-07-3
MF: C18H37N5O10•H2SO4
MW: 581.59
Highly potent antibiotic against Gram-negative bacteria often used in cell culture.

Kanamycin B sulfate (CAS 29701-07-3)

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Kanamycin B sulfate is rated 5.0 out of 5 by 1.
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Noms alternatifs: Bekanamycinsulfate salt
Application: Kanamycin B sulfate is highly potent antibiotic against Gram-negative bacteria often used in cell culture
Numéro CAS: 29701-07-3
Pureté: ≥95%
Masse Moléculaire: 581.59
Formule Moléculaire: C18H37N5O10•H2SO4
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
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Kanamycin B is an aminoglycoside with antibiotic properties that associates with bacterial ribosomal RNA. The compound is highly potent against gram-negative bacteria. Other members of the aminoglycoside group include Kanamycin A (sc-205358) and Amikacin (sc-202457). Kanamycin B has five amino groups and has a stronger association with acidic phospholipids in comparison to Kanamycin A. Studies have shown that the Kcat value of the kanamycin group is higher compared to the neomycin group.


Références

1. Basak, K. and Majumdar, S.K. 1973. Antimicrob. Agents Chemother. 4: 6-10. PMID: 4791483
2. Yung, M.W. and Green, C. 1987. J. Antibiot. 40: 862-867. PMID: 3610836
3. Carrier, D., et al. 1997. Biochem. Pharmacol. 53: 401-408. PMID: 9065744
4. Kwon, M., et al. 2001. Mol. Cells. 11: 303-311. PMID: 11459219
5. Norris, A.L., et al. 2010. Biochemistry. 49: 4027-4035. PMID: 20387903

Apparence :
Crystalline powder
État Physique :
Solid
Dérivé de :
Streptomyces kanamyceticus
Solubilité :
Soluble in water (50 mg/ml), and aqueous solution (92.3 mg/ml).
STOCKAGE :
Store at -20° C
Point d'Ébullition :
807.7° C at 760 mmHg (Predicted)
Indice de Réfraction :
n20D 1.67 (Predicted)
IC50 :
Bacillus subtilis: IC50 = 0.39 ug.mL-1; Staphylococcus aureus: IC50 = 1.56 ug.mL-1; Mycobacterium tuberculosis: IC50 = 2.5 ug.mL-1; Escherichia coli: IC50 = 3.13 ug.mL-1; Pseudomonas aeruginosa: IC50 = 3.13 ug.mL-1
Pour la Recherche Uniquement. Non conforme pour le Diagnostic ou pour une Utilisation Thérapeutique.
RTECS :
WK1976500
PubChem CID :
Index Merck :
14: 5281
Numéro CE :
225-170-5

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