Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
ACCÈS RAPIDE AUX LIENS
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
The Insulin receptor substrate (IRS) proteins are key components in signaling from the Insulin receptor. IRS-4 is the most recently characterized member of the IRS family and has an undefined in vivo function. Phosphorylated IRS-4 associates with phosphatidylinositol 3-kinase (PI3-kinase), involved in Insulin-stimulated DNA synthesis, GH-induced tyrosine phosphorylation of IRS-4 and nuclear translocation of Stat5. IRS-4 also associates with IRAS which, when overexpressed, enhances IRS-4-dependent Insulin stimulation of PI3-kinase. The IRS-4 protein exhibits a limited fiber type specific expression in heart and skeletal muscle tissue and has not yet been detected in any mouse or primary human tissue. The absence of IRS-4 in mice causes mild defects in growth, reproduction and glucose homeostasis, while overexpression of IRS-4 increases basal PI3-kinase activity and Akt phosphorylation. Defects in IRS-4-null mice may result from a lower overall blood glucose concentration.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Which IRS4 epitope is recognized by the antibody? Is it N-terminal within the amino acids 3-342? Thank you.
Posée par: thegut
Thank you for your question. The exact epitope used to raise this monoclonal antibody has not been mapped so we are unable to provide this information. Please contact our Technical Service Department for further support. We are happy to help perform sequence analysis for you to answer any specific questions you have about the antibody reactivity.
Répondue par: SCBT Heidelberg Support
Date de publication: 2018-12-30
For Western Blot, is it recommended to use denatured or non-denatured conditions with IRS-4 (RI-7): sc-100854 antibody?
Posée par: Trav11
Thank you for your question. We recommend this antibody for use in denatured Western Blot conditions. It has not been validated for use in non-denatured conditions. Please contact our Technical Service Department for further details or inquiries.
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