Les Produits Chimiques ChemCruz™
IL-6 Inhibiteurs pour l'analyse fonctionnelle des réponses cellulaires de IL-6
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
ACCÈS RAPIDE AUX LIENS
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Interleukin-6, or IL-6, is a multifunctional protein, 212 amino acids in length, that plays critical roles in host defense, immune response and hematopoiesis. IL-6 is constitutively expressed by epidermal Langerhans cells and its expression is induced in stimulated keratinocytes. IL-6, IL-1β and TNFα act as endogenous pyrogens, regulating the fever response to bacterial invasion. The IL-6 receptor is a trimeric complex composed of an IL-6-specific α chain and a homodimer of the gp130 glycoprotein common to the IL-6, IL-11, CNTF, OSM and LIF receptors. Stimulation with IL-6 leads to gp130 homodimerization and the activation of associated kinases JAK1 and JAK2. Once activated, JAK1 and JAK2 phosphorylate Stat3, causing its nuclear translocation and transcription of Stat3-responsive genes. IL-6 has also been shown to activate the Ras/MAP kinase pathway, which regulates NFIL6 transcription.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Thank you for your question. IL-6 has an expected molecular weight of approximately 21 kDa. If you have any questions, please contact our Technical Service Department and we would be happy to assist you.
Rated 1 de
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Date de publication: 2020-05-06
Rated 3 de
It doesn't work in WB of secretome of C2C12We have used this antibody to detect Il6 on conditioned medium of C2C12 cells at 1:1000 diluition and it doesn't work. It could be that the amount of IL6 produced by these cells is too low
Date de publication: 2018-10-05
Rated 5 de
Works well in rat frozen liver sectionsRat liver frozen sections were subjected to immunofluorescence using IL-6 (10E5) antibody. Antigen retrieval methods were optimized between without antigen retrieval, heat-induced citrate buffer, and trypsin-induced antigen retrieval. Positive signals in portal tracts were clear without any antigen retrieval.
Date de publication: 2018-03-14
Rated 5 de
Y F L par
Work very wellHave been using this antibody for Western blot detecting IL-6 in mouse tissue and C2C12 samples. Always got clear, specific band. would like to recommend it.
Date de publication: 2018-03-11
Rated 4 de
Santa Li par
Good!I got a small sample and tried it for WB in a dilution of 1:300. The results were great.
Date de publication: 2018-03-02
Rated 5 de
you siring par
good featureswork well in WB at 1:500, with hippocampus of mice.but, it has two bands, one is about 28kd,another is 20kd. So,which one is what i need?
Date de publication: 2018-02-01
Rated 5 de
TK IN par
Skeletal muscle immunostainingBright staining of nuclei in frozen skeletal muscle samples.
Date de publication: 2017-11-22
Rated 4 de
Good antibodyformalin fixed rat brain , IF staining, 1:100 dilution. got good result
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