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GIGYF2 (GRB10 interacting GYF protein 2), also known as GYF2, PERQ2, PERQ3, PARK11 or TNRC15, is a 1,299 amino acid protein that may be involved in the regulation of tyrosine kinase receptor signaling, including IGF-I and insulin receptors. Belonging to the PERQ family of proteins, GIGYF2 contains long stretches of glutamine and glutamic acid residues. Mutations in the gene encoding GIGYF2 are the cause of Parkinson disease type 11 (PARK11), which is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Parkinson's disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK11 may show age-dependent or reduced penetrance. GIGYF2 exists as two alternatively spliced isoforms.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps GIGYF2 (G-5) | sc-514546 | 200 µg/ml | $316.00 | |||
GIGYF2 (G-5): m-IgG2b BP-HRP Kit | sc-548629 | 200 µg Ab; 10 µg BP | $354.00 | |||
GIGYF2 (G-5) peptide neutralisant | sc-514546 P | 100 µg/0.5 ml | $68.00 |