Molecular structure of DPO-1, CAS Number: 43077-30-1
DPO-1 (CAS 43077-30-1)
Alternate Names:
Diphenyl phosphine oxide-1; [1S-(1α,2α,5β)]-[5-Methyl-2-(1-methylethyl)cyclohexyl]diphenylphosphine oxide
Application:
DPO-1 is a blocker of Kv1.5 channel and IKur ultra rapid delayed rectifier potassium current
CAS Number:
43077-30-1
Purity:
≥99%
Molecular Weight:
340.44
Molecular Formula:
C22H29OP
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
DPO-1 is a blocker of Kv1.5 channel and IKur ultrarapid delayed rectifier potassium current. (IC50 = 0.31 muM for rKV1.5). Displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinanant KV1.5 over KV3.1 (~ 15-fold). Increases action potential duration in atrial but not ventricular myocytes and prevents atrial arrhythmia.
DPO-1 (CAS 43077-30-1) References
- In vivo cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker, (2-Isopropyl-5-methylcyclohexyl) diphenylphosphine oxide, in rat and nonhuman primate. | Regan, CP., et al. 2006. J Pharmacol Exp Ther. 316: 727-32. PMID: 16243963
- Molecular determinants of Kv1.5 channel block by diphenyl phosphine oxide-1. | Du, YM., et al. 2010. J Mol Cell Cardiol. 48: 1111-20. PMID: 20184887
- Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries. | Moral-Sanz, J., et al. 2011. Am J Physiol Cell Physiol. 301: C186-94. PMID: 21490312
- Potent suppression of Kv1.3 potassium channel and IL-2 secretion by diphenyl phosphine oxide-1 in human T cells. | Zhao, N., et al. 2013. PLoS One. 8: e64629. PMID: 23717641
- Diphenyl phosphine oxide-1-sensitive K(+) channels contribute to the vascular tone and reactivity of resistance arteries from brain and skeletal muscle. | Fancher, IS., et al. 2015. Microcirculation. 22: 315-25. PMID: 25808400
- The Role of DPO-1 and XE991-Sensitive Potassium Channels in Perivascular Adipose Tissue-Mediated Regulation of Vascular Tone. | Tsvetkov, D., et al. 2016. Front Physiol. 7: 335. PMID: 27540364
- Shaker-related voltage-gated K+ channel expression and vasomotor function in human coronary resistance arteries. | Nishijima, Y., et al. 2018. Microcirculation. 25: PMID: 29161755
- miR-1 is increased in pulmonary hypertension and downregulates Kv1.5 channels in rat pulmonary arteries. | Mondejar-Parreño, G., et al. 2019. J Physiol. 597: 1185-1197. PMID: 29717493
- The muscarinic receptor antagonist tolterodine inhibits voltage-dependent K+ channels in rabbit coronary arterial smooth muscle cells. | Seo, MS., et al. 2020. Eur J Pharmacol. 870: 172921. PMID: 31935397
- Kv1.5 channel mediates monosodium urate-induced activation of NLRP3 inflammasome in macrophages and arrhythmogenic effects of urate on cardiomyocytes. | Li, P., et al. 2022. Mol Biol Rep. 49: 5939-5952. PMID: 35368226
- Asenapine, an atypical antipsychotic, blocks voltage-gated potassium channels in rabbit coronary artery smooth muscle cells. | Seo, MS., et al. 2022. Eur J Pharmacol. 934: 175318. PMID: 36209925
- Mechanism of canagliflozin-induced vasodilation in resistance mesenteric arteries and the regulation of systemic blood pressure. | Hasan, A., et al. 2022. J Pharmacol Sci. 150: 211-222. PMID: 36344043
- Sigma-1 receptor modulation fine-tunes KV1.5 channels and impacts pulmonary vascular function. | Vera-Zambrano, A., et al. 2023. Pharmacol Res. 189: 106684. PMID: 36740150
Inhibitor of:
KALIG-1, and KV1.5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
DPO-1, 10 mg | sc-203570 | 10 mg | $170.00 | |||
| US: Only available in the US | ||||||
DPO-1, 50 mg | sc-203570A | 50 mg | $715.00 | |||
| US: Only available in the US | ||||||