Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
ACCÈS RAPIDE AUX LIENS
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Cytokeratin 15 and Cytokeratin 18 (also designated KRT15, Keratin 15 antibody, KRT18 antibody, or Keratin 18 antibody) comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins are useful markers of tissue differentiation and, therefore, the characterization of malignant tumors. Cytokeratin 15 is an intermediate filament (IF) type I protein that is responsible for the mechanical integrity of epithelial cells. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for diagnosis between basal cell carcinoma and trichoepithelioma. Cytokeratin 18 is involved in keratin organization and distribution. Phosphorylation of Ser 18 of Cytokeratin 18 is essential for its association with 14-3-3 proteins. Cytokeratin 18 is expressed in a majority of adenocarcinomas and basal cell carcinomas.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
I am using Cytokeratin 15/18 (LC18N): sc-53254 for immunofluorescence, what dilution of this antibody should I use?
Posée par: Cweed
Thank you for your question. We recommend a starting dilution of 1:50. However, optimal antibody concentration should be determined by titration. Please find our full immunofluorescence protocol here:
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