CD45 Antibody (OX1): sc-53045

CD45 Antibody (OX1) is a mouse monoclonal IgG1 kappa light chain antibody designed to target CD45, also known as Protein Tyrosine Phosphatase Receptor Type C (PTPRC). CD45 is a crucial transmembrane glycoprotein expressed on all nucleated hematopoietic cells in humans, mice, and rats, playing a vital role in regulating immune cell function. CD45 acts as a tyrosine phosphatase, which is essential for modulating signal transduction pathways involved in T and B cell receptor signaling. By dephosphorylating key tyrosine residues on Src family kinases such as Lck and Fyn, as well as on Syk family kinases like ZAP-70, CD45 controls the activation, proliferation, and differentiation of lymphocytes, thereby maintaining immune system homeostasis and ensuring effective immune responses. Anti-CD45 antibody (OX1) is raised against full-length thymocyte membrane glycoproteins of rat origin, providing broad reactivity across multiple species including mouse, rat, and human. CD45 monoclonal antibody (OX1) is versatile and suitable for various applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA), making CD45 (OX1) antibody an indispensable tool for both research and diagnostic purposes. Anti-CD45 antibody (OX1) facilitates comprehensive analysis of immune cell populations and their signaling mechanisms, enabling detailed studies in immunology, hematology, and related fields. CD45 monoclonal antibody (OX1) is essential for advancing our understanding of immune system dynamics and developing targeted therapies for immune-related diseases.

The preferred CD45 antibody is CD45 Antibody (35-Z6): sc-1178.