CASIN CAS: 425399-05-9
MF: C20H22N2O
MW: 306.40
A Cdc42 GTPase inhibitor.

CASIN (CAS 425399-05-9)

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Noms alternatifs: 2-[(2,3,4,9-Tetrahydro-6-phenyl-1H-carbazol-1-yl)amino]ethanol
Application: CASIN is a Cdc42 GTPase inhibitor
Numéro CAS: 425399-05-9
Pureté: ≥98%
Masse Moléculaire: 306.40
Formule Moléculaire: C20H22N2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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CASIN is a Cdc42 GTPase inhibitor (IC50 = 2 μM). It reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs and reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs. CASIN also increases histone H4K16 acetylation in aged HSCs.

État Physique :
Solid
Solubilité :
Soluble in DMSO (100 mM), and ethanol (50 mM).
STOCKAGE :
Store at -20° C
Point de fusion :
215.08° C (Predicted)
Point d'Ébullition :
~577.8° C at 760 mmHg (Predicted)
Densité :
~1.2 g/cm3 (Predicted)
Indice de Réfraction :
n20D 1.68 (Predicted)
IC50 :
Cdc42 GTPase: IC50 = 2 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)C4=CC=CC=C4)NCCO

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CERTIFICAT D'ANALYSE

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CASIN (CAS 425399-05-9)  Références bibliographiques

Consultez les publications faisant référence à l' utilisation de CASIN (CAS 425399-05-9). Cliquez sur le lien pour afficher lentrée PubMed .

Citations 1 à 1 sur un total de 1

PMID: # 32198058  Microvasc. Res. 130: 104001.

Citations 1 à 1 sur un total de 1
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