CASIN is a Cdc42 GTPase inhibitor (IC50 = 2 μM). It reduces active levels of Cdc42 in aged hematopoietic stem cells (HSCs) to that in young HSCs and reverses the aging-related and polarity phenotype of aged HSCs to that of young HSCs. CASIN also increases histone H4K16 acetylation in aged HSCs.
Consultez les publications faisant référence à l' utilisation de CASIN (CAS 425399-05-9). Cliquez sur le lien pour afficher lentrée PubMed .
PMID: # 32198058 Microvasc. Res. 130: 104001.