Anticorps BCRF1 (S30): sc-73736

Interleukin-10, or IL-10, is a 178 amino acid protein that is primarily secreted by TH2 clones. IL-10 has dual functions, the first of which is the suppression of cytokine production by TH1 clones responding to antigen presented by monocyte and macrophage antigen presenting cells (APCs). The second function consists of the inhibition of response of cytokine targeted cells, possibly by the downregulation of CD25 (the IL-2 receptor) on macrophages and B lymphocytes. Human and murine IL-10 exhibit 81% sequence identity at the amino acid level and share 73% identity at the cDNA level. Both human and murine IL-10 are acid-liable and exist as non-covalently-linked homodimers in solution. IL-10 exerts its biological activity through the IL-10 receptor (IL-10R), a glycoprotein whose expression can be induced in cultured macrophages and fibroblasts by lipopolysaccharide (LPS) stimulation. IL-10 expression has been shown to be elevated in HIV-1 infected individuals and has been implicated in the progression of the disease.