Anticorps AKAP 95 (47): sc-135828
- L'anticorps AKAP 95 47 est un monoclonal IgG2b de souris fourni en 50 µg/0.5 ml
- dirigé contre les acides aminés 460-781 de AKAP 95 d'origine human
- recommandé pour la détection de AKAP 95 d'origine human par WB, IP et IF
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire AKAP 95 (47). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP). AKAP 95, also known as AKAP 8, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle. During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression. Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit. In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps AKAP 95 (47) | sc-135828 | 50 µg/0.5 ml | $316.00 |