Anticorps AKAP 10 (E-7): sc-166192
- L'Anticorps AKAP 10 (E-7) est un monoclonal de souris IgG2a (chaîne légère kappa) fourni en 200 µg/ml
- soulevée à l'encontre des acides aminés 508-662 correspondant à C-terminus de AKAP 10 d'origine human.
- recommandé pour la détection de AKAP 10 d'origine human par WB, IP, IF et ELISA
- 2a BP-HRP">m-IgG2a BP-HRP est le réactif de détection secondaire préféré pour l'anticorps AKAP 10 (E-7) pour les applications WB. Ce réactif est désormais proposé en association avec l'anticorps AKAP 10 (E-7)(voir les informations relatives à la commande ci-dessous).
ACCÈS RAPIDE AUX LIENS
The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the regulatory (R) subunits (RI and RII) of PKA interact with specific R-anchoring proteins designated AKAPs (A-kinase anchoring proteins). AKAP 10 (A kinase anchor protein 10), also known as PRKA10 or D-AKAP2 (dual-specific A kinase-anchoring protein 2), is a 662 amino acid mitochondrial membrane protein that belongs to the AKAP family. AKAP 10 is a dual specificity protein that binds to both type I and type II regulatory subunits of PKA and anchors them to the plasma membrane or the mitochondria. When anchored to the mitochondria, PKA can phosphorylate and, thus, inactivate the proapoptotic protein Bad. This suggests that AKAP 10 indirectly regulates Bad-induced apoptosis by mediating the mitochondrial attachment of PKA. Additionally, AKAP 10 may facilitate G-protein coupled signal transduction and could act as an adaptor in the assembly of multiprotein complexes.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps AKAP 10 (E-7) | sc-166192 | 200 µg/ml | $316.00 | |||
AKAP 10 (E-7): m-IgG2a BP-HRP Kit | sc-546028 | 200 µg Ab; 10 µg BP | $354.00 |