Y-27632 dihydrochlorideA cell permeable inhibitor of ROCK-1 and ROCK-2

Y-27632 dihydrochloride (CAS 129830-38-2)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 118ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
5
1
4
0
3
0
2
0
1
0
Sinónimo: ROCK Inhibitor
Solicitud: A cell permeable inhibitor of ROCK-1 and ROCK-2
Número de CAS: 129830-38-2
Pureza: ≥98%
Peso Molecular: 320.26
Fórmula Molecular: C14H21N3O•2HCl
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).
Envíe una reseña para este producto y reciba 15 créditos Cruz

Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2.


References

1. Uehata, M., et al., 1997. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 389(6654): 990-4. PMID: 9353125

2. Itoh, K., et al., 1999. An essential part for Rho-associated kinase in the transcellular invasion of tumor cells. Nature medicine. 5(2): 221-5. PMID: 9930872

3. Davies, S P., et al., 2000. Specificity and mechanism of action of some commonly used protein kinase inhibitors. The Biochemical journal. 351(Pt 1): 95-105. PMID: 10998351

4. Narumiya, S., et al., 2000. Use and properties of ROCK-specific inhibitor Y-27632. Methods in enzymology. 325(): 273-84. PMID: 11036610

5. Köksel, Oğuz., et al., 2005. Rho-kinase (ROCK-1 and ROCK-2) upregulation in oleic acid-induced lung injury and its restoration by Y-27632. European journal of pharmacology. 510(1-2): 135-42. PMID: 15740734

6. Fernandes, Lynette., et al., 2006. A Rho-kinase inhibitor, Y-27632, reduces cholinergic contraction but not neurotransmitter release. European journal of pharmacology. 550(1-3): 155-61. PMID: 17010334


Estado de Materia :
Solid
Solubilidad :
Soluble in water (14 mg/mL), ethanol (~5 mg/mL), DMSO (~20 mg/mL), DMF (~30 mg/mL), PBS, pH 7.2 (~10 mg/mL), and methanol (25 mg/mL).
ALMACENAMIENTO :
Store at -20° C
Indice de Refracción :
n20D 1.58
Actividad Óptica :
α20/D +7°, c = 0.4 in methanol
IC50 :
ROCK-II: IC50 = 800 nM; PRK2: IC50 = 600 nM; Smooth-muscle contraction induces by various agonists including phenylephrine, histamine, acetylcholine, serotonin, endothelin, and thromboxane : IC50 = 0.3-1 µM
Datos Ki :
p160ROCK: Ki= 140 nM; cAMP-dependent protein kinase: Ki= 25 µM; PKC: Ki= 26 µM; Myosin light-chain kinase: Ki= >250 µM; ROCKI: Ki= 0.22 µM; ROCKII: Ki= 0.3 µM; PKCα: Ki= 73 µM
Valores de pK :
pKa: 13.53 (Predicted), pKb: 10.74 (Predicted)
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
PubChem CID :
9901617
Número MDL :
MFCD03490488
SMILES :
C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

Necesita Adobe Acrobat Reader para ver de forma fiable,
imprimir y comentar el documento de PDF

Y-27632 dihydrochloride  Menciones del Producto

Ver como otros han utilizado Y-27632 dihydrochloride. Haga click en la entrada de PubMed .

Citaciones 1 a 10 de un total de 19

PMID: # 30776675  Kahounová, Z.|Slabáková, E.|Binó, L.|Remšík, J.|Fedr, R.|Bouchal, J.|Vrtěl, R.|Jurečková, L.|Porokh, V.|Páralová, D.|Hampl, A.|Souček, K.| et al. 2019. Stem Cell Res. 35: 101405.

PMID: # 30481741  Kahounová, Z.|Slabáková, E.|Binó, L.|Remšík, J.|Fedr, R.|Bouchal, J.|Kurfűrstová, D.|Vrtěl, R.|Študent, V.|Jurečková, L.|Porokh, V.|Hampl, A.|Souček, K.| et al. 2018. Stem Cell Res. 33: 255-259.

PMID: # 28383825  Kahounová, Z.|Kurfürstová, D.|Bouchal, J.|Kharaishvili, G.|Navrátil, J.|Remšík, J.|Šimečková, Š.|Študent, V.|Kozubík, A.|Souček, K.| et al. 2018. Cytometry A. 93: 941-951.

PMID: # 30211124  Bahmad, HF. et al. 2018. Front Oncol. 8: 347.

PMID: # 28753427  Gupta, RM.|Hadaya, J.|Trehan, A.|Zekavat, SM.|Roselli, C.|Klarin, D.|Emdin, CA.|Hilvering, CRE.|Bianchi, V.|Mueller, C.|Khera, AV.|Ryan, RJH.|Engreitz, JM.|Issner, R.|Shoresh, N.|Epstein, CB.|de Laat, W.|Brown, JD.|Schnabel, RB.|Bernstein, BE.|Kathiresan, S.| et al. 2017. Cell. 170: 522-533.e15.

PMID: # 28837677  Au, ED.|Fernandez-Godino, R.|Kaczynksi, TJ.|Sousa, ME.|Farkas, MH.| et al. 2017. PLoS ONE. 12: e0183939.

PMID: # 29216888  Wang, H. et al. 2017. BMC Biol. 15: 114.

PMID: # 29182622  Vondálová Blanářová, O.|Šafaříková, B.|Herůdková, J.|Krkoška, M.|Tománková, S.|Kahounová, Z.|Anděra, L.|Bouchal, J.|Kharaishvili, G.|Král, M.|Sova, P.|Kozubík, A.|Hyršlová Vaculová, A.| et al. 2017. PLoS ONE. 12: e0188584.

PMID: # 28104444  Ghasemi, A. et al. 2017. Cell. Signal. 32: 104-114.

PMID: # 27596957  2016. Stem Cell Res. 17: 296-305.

Citaciones 1 a 10 de un total de 19
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 93ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 32ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. es un líder mundial en el desarrollo de productos para el mercado de la investigación biomédica. Llámenos gratis al 00 800 4573 8000.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved."Santa Cruz Biotechnology", y el logo de Santa Cruz Biotechnology, Inc., "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", el logo de San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", y "EZ Touch" son marcas registradas de Santa Cruz Biotechnology, Inc. Todas las marcas registradas son propiedad de su respectivo dueño.