WIKI4A potent inhibitor of Wnt/β-catenin signaling

WIKI4 (CAS 838818-26-1)

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Sinónimo: 2-[3-[[4-(4-Methoxyphenyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]propyl]-1H-benz[de]isoquinoline-1,3(2H)-dione
Solicitud: A potent inhibitor of Wnt/β-catenin signaling
Número de CAS: 838818-26-1
Peso Molecular: 521.59
Fórmula Molecular: C29H23N5O3S
* Refer to Certificate of Analysis for lot specific data (including water content).

WIKI4 is a potent inhibitor of Wnt/β-catenin signaling with an EC50 ~ 75 nM in all cell lines tested including DLD1 colorectal cancer cells, NALM6 B cells, U2OS osteosarcoma cells, and hESCs. WIKI4 inhibits auto-ADP-ribosylation of tankyrase 2 (TNKS2) with an IC50 of 15 nM, preventing the ubiquitination and degradation of axin and thereby antagonizing Wnt signalling.

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (10 mg/ml, clear, warmed).
ALMACENAMIENTO :
Store at -20° C
Punto de ebullición :
~783.1 °C at 760 mmHg (Predicted)
Densidad :
~1.4 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.72 (Predicted)
IC50 :
auto-ADP-ribosylation of tankyrase 2 (TNKS2): IC50 = 15 nM; Wnt/β-catenin signaling: EC5050 = ~75 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Alemania :
3
PubChem CID :
2984337
SMILES :
COC1=CC=C(C=C1)N2C(=NN=C2SCCCN3C(=O)C4=CC=CC5=C4C(=CC=C5)C3=O)C6=CC=NC=C6

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

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