Troponin I-C Antibody (10B11): sc-52266

Troponin I-C Antibody (10B11) is a mouse monoclonal IgG1 antibody designed to detect cardiac Troponin I (cTnI), also known as TNNI3, a crucial regulatory protein located within the sarcomere of cardiac muscle cells. Anti-Troponin I-C antibody (10B11) targets the epitope mapped to amino acids 16-20 of full-length human cardiac Troponin I, ensuring precise and reliable binding. Cardiac Troponin I plays a vital role in regulating cardiac muscle contraction by inhibiting the interaction between actin and myosin in the absence of calcium, thereby controlling the contraction and relaxation cycles essential for maintaining proper heart function. The precise localization of Troponin I within the cardiac sarcomere is critical for the dynamic regulation of muscle contraction in response to physiological demands. Troponin I-C monoclonal antibody (10B11) exhibits broad species reactivity, effectively recognizing both free and complexed forms of cardiac Troponin I from mouse, rat, human, porcine, feline, and canine origins, making this reagent versatile for various experimental models. Troponin I-C antibody (10B11) is compatible with multiple applications including western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA), facilitating comprehensive studies in cardiac physiology, disease mechanisms, and biomarker detection for cardiac injury. By targeting a key protein integral to cardiac muscle function, Troponin I-C (10B11) antibody serves as an indispensable tool for researchers investigating heart health, myocardial infarction, and the molecular underpinnings of cardiac diseases, thereby contributing to the advancement of diagnostic and therapeutic strategies.

The preferred Troponin I antibody is Troponin I Antibody (E-9): sc-365446.