Trapoxin A CAS: 133155-89-2
MF: C34H42N4O6
MW: 602.72
A cyclotetrapeptide HDAC inhibitor.

Trapoxin A  (CAS 133155-89-2)

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Nombres Alternativos: RF 1023A
Solicitud: Trapoxin A is a cyclotetrapeptide HDAC inhibitor
Número de CAS: 133155-89-2
Pureza: ≥98%
Peso Molecular: 602.72
Fórmula Molecular: C34H42N4O6
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).

Trapoxin A is a cyclotetrapeptide and an HDAC (histone deacetylase) inhibitor. Trapoxin increases the level of chromatin acetylation associated with histone H3 at low nanomolar concentrations. Unlike the reversible HDAC inhibition induced by TCA, Trapoxin irreversibly inhibits HDAC activity in crude cell lysates and induces the accumulation of hyperacetylated core histones in a number of mammalian cell lines and tissues. Histone acetylation and methylation have been studied extensively for their anti-tumor activities in carcinogenesis and Trapoxin has been suggested as a potential anticancer agent for pre-clinical trials.


References

1. Fang, J.Y., and Lu, Y.Y., Effects of histone acetylation and DNA methylation on p21 (WAF1) regulation. World J. Gastroenterol. 8, 400-405, (2002) 2. Yoshida, M., et al., Trichostatin A and Trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function. Bioessays 17, 423-430, (1995) 3. Vigushin, D.M., and Coombes, R.C., Histone deacetylase inhibitors in cancer treatment. Anti-Cancer Drugs 13, 1-13, (2002)

Estado de Materia :
Solid
Solubilidad :
DMSO: may be further diluted 20 fold in H2O soluble: chloroform: soluble: methanol: soluble
ALMACENAMIENTO :
Store at -20° C
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
Transporte :
UN 2811, Class 6.1, Packing group III
PubChem CID :
121875
SMILES :
C1CCN2[[email protected]](C1)C(=O)N[[email protected]](C(=O)N[[email protected]](C(=O)N[[email protected]](C2=O)CC3=CC=CC=C3)CC4=CC=CC=C4)CCCCCC(=O)[[email protected]@H]5CO5

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