Tetromycin B is an unusual tetronic acid structure, Tetromycin B has displayed pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. It is structurally similar to chlorothricin, kijanimicin, tetrocarcin, versipelostatin and saccharocarcin. Tetromycin B may also target the posphatidylinositide-3′-kinase/Akt signaling pathway, much like Tetromycin A.
1. Park, H.R., et al. 2004. J. Natl. Cancer Inst. 96: 1300-1310. PMID: 15339968
2. Nakajima, H., et al. 2007. Biochem. Biophys. Res. Commun. 356: 260-265. PMID: 17350598