TAK 165 CAS: 366017-09-6
MF: C25H23F3N4O2
MW: 468.47
A selective, potent, and irreversible ErbB2 and EGFR inhibitor.

TAK 165 (CAS 366017-09-6)

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Nombres Alternativos: Mubritinib
Solicitud: TAK 165 is a selective, potent, and irreversible ErbB2 and EGFR inhibitor
Número de CAS: 366017-09-6
Peso Molecular: 468.47
Fórmula Molecular: C25H23F3N4O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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TAK 165 is a potent Neu (HER2) and Cdc2 p34 inhibitor with IC50 of 6 nM and 0.2μM, respectively. TAK 165 also inhibits Cdk2 (p33cdk2) and Cdk5 (p33cdk5). TAK 165 displays > 4000-fold selectivity over EGFR, FGFR, PDGFR, JAK1 and Src. TAK 165 exhibits potent antiproliferative effects in Neu-overexpressing cancer cell lines (IC50 = 5 nM in BT474 breast cancer cells) and significantly inhibits bladder, breast and prostate cancer xenograft growth.


References

1. Nagasawa, J., et al. 2006. Int. J. Urol. 13: 587-592 .PMID: 16771730

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (25 mg/mL) with warming; ethanol (1.7 mg/mL), and water (<1 mg/mL).
ALMACENAMIENTO :
Store at -20° C
Punto de Fusión :
154-166° C
Punto de ebullición :
620.90° C at 760 mmHg (Predicted)
Densidad :
1.26 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.58 (Predicted)
IC50 :
epithelial growth factor receptor 2 (ErbB2): IC50 = 6 nM (human); antiproliferative effects in ErbB2-overexpressing cancer cell lines: IC50 = 5 nM ( BT474 breast cancer cells); p34cdc2: IC50 = 0.2 µM
Valores de pK :
pKb: 1.45 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
Número MDL :
MFCD09954135
SMILES :
C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)/C=C/C4=CC=C(C=C4)C(F)(F)F

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

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