SR 95531 Hydrobromide is a selective GABAA receptor antagonist. This compound displaces [3H]-GABA with a Ki of 150 nM. SR 95531 Hydrobromide selectively antagonizes GABA-induced Cl- currents with little action on pentobarbitone-induced currents. SR 95531 Hydrobromide acts as a low affinity GlyR(glycine receptor)antagonist.
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Estado de Materia
Soluble in water (>10 mg/ml), DMSO (100 mM), ethanol (20 mM), and phosphate buffered saline (5 mM).
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