Anti-SgK223 Anticuerpo A-6 es un monoclonal de ratón IgG1 κ SgK223 Anticuerpo, ver las 2 publicaciones, proporcionado como 200 µg/ml
producido contra los amino ácidos 1-56 localizados en el N-terminus de SgK223 de origen human
SgK223 Anticuerpo (A-6) es recomendado para detectar SgK223 de mouse, rat y human origen, mediante WB, IP, IF y ELISA
SgK223 Anticuerpo (A-6) es disponible conjugado a agarosa para IP; HRP para WB, IHC(P) y ELISA; y tanto a phycoerythrin como a FITC para IF, IHC(P) y FCM
también disponible conjugado a Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 o Alexa Fluor® 647 para WB (RGB), IF, IHC (P) y FCM
también disponible conjugado a Alexa Fluor® 680 o Alexa Fluor® 790 para WB (NIR), IF y FCM
Contacte con nosotros para recibir GRATIS 10 µg de muestra de SgK223 (A-6): sc-398164.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SgK223 Antibody (A-6) for WB applications. These reagents are now offered in bundles with SgK223 Antibody (A-6) (see ordering information below).
SGK Inhibitorspara análisis funcionales de las repuestas celulares a SGK
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Animal Health Prescription Item
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Labware ships FedEx Ground free of charge to the contiguous US
SgK223 Antibody (A-6) is a high quality monoclonal SgK223 antibody (also designated SgK223 antibody) suitable for the detection of the SgK223 protein of mouse, rat and human origin. SgK223 Antibody (A-6) is available as both the non-conjugated anti-SgK223 antibody form, as well as multiple conjugated forms of anti-SgK223 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The Ras p21 family of guanine nucleotide proteins has been widely studied in view of its role in signal transduction pathways and high frequency of mutations in human malignancies. The founding members of the Ras family (H-, K- and N-Ras p21) are members of a much larger superfamily of related proteins. Six members of this family, Rap 1A, Rap 1B, Rap 2, R-Ras, Ral A and Ral B, exhibit approximately 50% amino acid homology to Ras. The mammalian Rho proteins (Rho A, B, C, 6, 7 and 8) are approximately 30% homologous to Ras and are expressed in a wide range of cell types. Three Rho-related GTPases Rnd1 (Rho 6), Rnd2 (Rho 7), and Rnd3 (Rho 8 or Rho E) form a distinct branch of the Rho family since they differ from other Rho proteins in size, charge, and biochemical properties. Rnd proteins are likely to be farnesylated, and appear to be constitutively in the activated GTP-bound form. Rnd proteins act as negative regulators of Actin assembly and of cell adhesion. Rnd2 binds to SgK223 (sugen kinase 223) in a GTP-dependent manner. Rnd2-bound SgK223 stimulates Rho A activity and induces cell contraction to regulate neurite outgrowth.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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