SGK Anticuerpo (H-4) es un monoclonal de ratón IgG2b κ, ver las 12 publicaciones, proporcionado como 200 µg/ml
specific for an epitope mapping between 400-425 containing Ser 422 of SGK of human origin
SGK Anticuerpo (H-4) es recomendado para detectar SGK de mouse, rat y human origen, mediante WB, IP, IF, IHC(P) y ELISA
SGK Anticuerpo (H-4) es disponible conjugado a agarosa para IP; HRP para WB, IHC(P) y ELISA; y tanto a phycoerythrin como a FITC para IF, IHC(P) y FCM
también disponible conjugado a Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 o Alexa Fluor® 647 para WB (RGB), IF, IHC (P) y FCM
también disponible conjugado a Alexa Fluor® 680 o Alexa Fluor® 790 para WB (NIR), IF y FCM
Contacte con nosotros para recibir GRATIS 10 µg de muestra de SGK (H-4): sc-28338.
m-IgG Fc BP-HRP (mouse IgG Fc binding protein-HRP) is the preferred secondary detection reagent for SGK Antibody (H-4) for WB and IHC(P) applications. This reagent is now offered in a bundle with SGK Antibody (H-4) (see ordering information below).
SGK para análisis funcionales de las repuestas celulares a SGK
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Labware ships FedEx Ground free of charge to the contiguous US
Serum- and glucocorticoid-regulated kinase (SGK), also known as SGK1, is a serine/threonine protein kinase and a member of the "AGC" subfamily, which includes protein kinases A, G, and C. SGK plays an important role in activating certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. SGK contains a catalytic domain, which is most similar to Akt1 (also known as protein kinase B or PKB). SGK is a downstream target of PI 3-kinase-stimulated growth factor signaling, with 3-phosphoinositide-dependent protein kinase 1 (PDK1) capable of phosphorylating the activation-loop of SGK at Threonine-256. The adrenal corticosteroid hormone, Aldosterone, induces the transcription of SGK, which mediates Na + transport by stimulating epithelial sodium channel activity. The SGK promoter contains a glucocorticoid response element and an SP-1 regulatory element, and is a transcriptional target for p53. SGK is also a component of the p38 MAPK-mediated response to hyperosmotic stress. The human SGK gene maps to chromosome 6q23 and encodes the 431-amino acid SGK protein.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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