Molecular structure of Ro 08-2750, CAS Number: 37854-59-4
Ro 08-2750 (CAS 37854-59-4)
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Alternate Names:
2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
Application:
Ro 08-2750 is a TrkA inhibitor and NGF-induced apoptosis inhibitor
CAS Number:
37854-59-4
Molecular Weight:
270.24
Molecular Formula:
C13H10N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ro 08-2750 is an inhibitor of NGF-induced apoptosis. At submicromolar concentrations, Ro 08-2750 inhibits binding selectively to p75NTR. At higher concentrations, Ro 08-2750 inhibits binding selectively to P75NTR and TrkA. In SK-N-MC cells, it prevents NGF-induced apoptosis. Ro 08-2750 is an inhibitor of NGFR. Ro 08-2750 holds great significance in the realm of organic chemistry. Its remarkable properties have garnered considerable attention in recent times, leading to extensive research across multiple scientific domains. Ro 08-2750 serves as a building block in the creation of diverse compounds, making it an invaluable intermediate in various synthesis processes.
Ro 08-2750 (CAS 37854-59-4) References
- Identification of novel pyrazoloquinazolinecarboxilate analogues to inhibit nerve growth factor in vitro. | Eibl, JK., et al. 2013. Eur J Pharmacol. 708: 30-7. PMID: 23528360
- Nerve growth factor promotes expression of novel genes in intervertebral disc cells that regulate tissue degradation: Laboratory investigation. | Kao, TH., et al. 2014. J Neurosurg Spine. 21: 653-61. PMID: 25062286
- Nerve growth factor increases MMP9 activity in annulus fibrosus cells by upregulating lipocalin 2 expression. | Kao, TH., et al. 2015. Eur Spine J. 24: 1959-68. PMID: 25412834
- Characterizing nerve growth factor-p75(NTR) interactions and small molecule inhibition using surface plasmon resonance spectroscopy. | Sheffield, KS., et al. 2016. Anal Biochem. 493: 21-6. PMID: 26435172
- Using surface plasmon resonance spectroscopy to characterize the inhibition of NGF-p75(NTR) and proNGF-p75(NTR) interactions by small molecule inhibitors. | Sheffield, KS., et al. 2016. Pharmacol Res. 103: 292-9. PMID: 26675716
- Increased expression and activity of p75NTR are crucial events in azacitidine-induced cell death in prostate cancer. | Gravina, GL., et al. 2016. Oncol Rep. 36: 125-30. PMID: 27222100
- Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells. | Chakravarthy, R., et al. 2016. Biochem Biophys Res Commun. 478: 1541-7. PMID: 27577679
- Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. | Minuesa, G., et al. 2019. Nat Commun. 10: 2691. PMID: 31217428
- Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease. | Lim, CT., et al. 2021. Biochem J. 478: 2517-2531. PMID: 34198325
- Musashi-2 contributes to myotonic dystrophy muscle dysfunction by promoting excessive autophagy through miR-7 biogenesis repression. | Sabater-Arcis, M., et al. 2021. Mol Ther Nucleic Acids. 25: 652-667. PMID: 34589284
- NGF Signaling Interacts With the Hippo/YAP Pathway to Regulate Cervical Cancer Progression. | Wang, L., et al. 2021. Front Oncol. 11: 688794. PMID: 34722240
- Autophagic Schwann cells promote perineural invasion mediated by the NGF/ATG7 paracrine pathway in pancreatic cancer. | Zhang, W., et al. 2022. J Exp Clin Cancer Res. 41: 48. PMID: 35109895
- TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma. | Erazo, T., et al. 2022. Nat Commun. 13: 5676. PMID: 36167829
Inhibitor of:
Apoptosis, GDNF, NGF, NGFR, and NTT4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro 08-2750, 1 mg | sc-203682 | 1 mg | $188.00 | |||
| US: Only available in the US | ||||||
Ro 08-2750, 10 mg | sc-203682A | 10 mg | $416.00 | |||
| US: Only available in the US | ||||||