Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (Cdks). IC50 values are 4, 70, 35, 850 and 75 nM for cdc2/cyclin B, cdk2/cyclin A, cdk2/cyclin E, cdk4/cyclin D1 and cdk5-p35 respectively. Purvalanol A reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.
Estado de Materia
Soluble in methylene chloride (50 mg/ml), DMSO (100 mg/ml), ethanol (50 mM), methanol, and dichloromethane.
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