PluriSln 1 (CAS 91396-88-2)
Sinónimo:
4-Pyridinecarboxylic acid 2-phenylhydrazide
Solicitud:
A SCD1 inhibitor and apoptosis inducer
Número de CAS:
91396-88-2
Peso Molecular:
213.24
Fórmula Molecular:
C12H11N3O
* Refer to Certificate of Analysis for lot specific data (including water content).
PluriSln 1 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1). It is useful for eliminating undifferentiated human pluripotent stem cells (hPSCs) from culture by selectively inducing apoptosis in these cells. Additionally, pluriSln 1 induces endoplasmic reticulum stress, reduces protein synthesis, and prevents teratoma formation in immunocompromised mice models.
References
1. Ben-David, Uri., et al., 2013. Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell stem cell. 12(2): 167-79. PMID: 23318055
Estado de Materia
:
Solid
ALMACENAMIENTO
:
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID
:
225362
SMILES
:
C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2
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CERTIFICADO DE ANÁLISIS
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