Neuronal Differentiation Inducer IIIA neuronal differentiation inducing compound

Neuronal Differentiation Inducer III (CAS 832115-62-5)

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Sinónimo: N-cyclopropyl-5-thiophen-2-yl-1,2-oxazole-3-carboxamide
Solicitud: A neuronal differentiation inducing compound
Número de CAS: 832115-62-5
Pureza: ≥97%
Peso Molecular: 234.27
Fórmula Molecular: C11H10N2O2S
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Neuronal Differentiation Inducer III is a cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 μM) in various stem/progenitor cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type channel-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.


References

1. Schneider, Jay W., et al., 2008. Small-molecule activation of neuronal cell fate. Nature chemical biology. 4(7): 408-10. PMID: 18552832

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (100 mM), and ethanol (50 mM).
ALMACENAMIENTO :
Store at 4° C
Punto de Fusión :
175.40° C (Predicted)
Punto de ebullición :
468.09° C at 760 mmHg (Predicted)
Densidad :
1.40 g/cm3 (Predicted)
Indice de Refracción :
n20D 1.64 (Predicted)
Valores de pK :
pKa: 13.6 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
19582717
SMILES :
C1CC1NC(=O)C2=NOC(=C2)C3=CC=CS3

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CERTIFICADO DE ANÁLISIS

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