Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
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Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
MYL3 Antibody (MLM508) is a high quality monoclonal MYL3 antibody (also designated MYL3 antibody) suitable for the detection of the MYL3 protein of human and rat origin. MYL3 Antibody (MLM508) is available as the non-conjugated anti-MYL3 antibody. Myosin, the major component of thick muscle filaments, is a long asymmetric molecule containing a globular head and a long tail. Activation of smooth and cardiac/ventricular muscle primarily involves pathways which increase calcium and myosin phosphorylation, resulting in contraction. Myosin in vertebrate striated muscle is composed of two heavy chains and four light chains. There are two distinct types of light chains: the phosphorylatable, regulatory or MLC2 type; and the nonphosphorylatable, alkali or MLC1 and MLC3 types. Myosin light chain phosphatase acts to regulate muscle contraction by de-phosphorylating activated myosin light chain. The role of myosin alkali light chains in vertebrate skeletal muscle is poorly understood, although alkali light chains in smooth muscle may be involved with the active site of myosin. Several isoforms of myosin alkali light chains have been identified, encoded by a family of myosin light chain genes. Each is associated with different muscle types. Human myosin light chain can be used as a cardiac marker. Myosin light chain 3, encoded by MYL3, is an alkali light chain also referred to as both the ventricular isoform (MLC1v) and slow skeletal muscle isoform. Myosin light chain 3 proteins in human and mouse share 91% sequence identity overall.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Can sc-47719: MYL3 (MLM508) monoclonal antibody be used to stain formalin-fixed, paraffin-embedded (FFPE) tissue sections?
Preguntado por: TinTin
Thank you for your question. Yes, sc-47719: MYL3 (MLM508) is recommended for use in IHC with paraffin-embedded sections. We recommend performing antigen retrieval with sodium citrate buffer (pH 6) and heat. The full protocol can be found here:
Rated 5 de
Work wellThe antibodies diluted 100 times I do sheep gastrocnemius immunohistochemical reaction, the effect is very good under the electron microscope photography, the experiment also in the works, concrete analysis of the results haven't come out.
Fecha de publicación: 2016-12-09
Rated 4 de
Cytoplasmic staining observed in paraffinCytoplasmic staining observed in paraffin-embedded human heart muscle tissue. -SCBT QC
Fecha de publicación: 2015-01-15
Rated 4 de
Worked well for Western blotWorked well for Western blot, positive data in rat heart tissue extract. -SCBT QC
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