MeBIO CAS: 667463-95-8
MF: C17H12BrN3O2
MW: 370.20
A control analog of BIO which displays minimal activity against CDK1/Cyclin B & GSK-3 α/β.

MeBIO (CAS 667463-95-8)

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Nombres Alternativos: 1-Methyl-BIO; (2'Z,3'E)-6-Bromo-1-methylindirubin-3'-oxime
Solicitud: MeBIO is a control analog of BIO which displays minimal activity against CDK1/Cyclin B & GSK-3 α/β
Número de CAS: 667463-95-8
Pureza: ≥99%
Peso Molecular: 370.20
Fórmula Molecular: C17H12BrN3O2
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).
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MeBIO is an analog of 6-bromoindirubin-3'-oxime (BIO, sc-202634), which acts as an aryl hydrocarbon receptor (AhR) agonist. MeBIO inhibits the phosphorylation of Tyr276/216, the active site on the enzyme GSK-3α/β, which suppresses the activity of the ezyme. GSK-3 is a serine/threonine protein kinase which inactivates glycogen synthase and mediates the phosphorylation of specific amino acids that contain serine and threonine. Studies indicate that MeBIO and other indirubins are beneficial tools, along with lithium and kenpaullone to study the cellular functions of GSK-3. MeBIO acts as a weak antagonist against CDK1/Cyclin B and CDK5/p25 activity.


References

1. Meijer, L., et al. 2003. Chem. Biol. 10: 1255-1266. PMID: 14700633
2. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47: 935-946. PMID: 14761195
3. Tseng, A.S., et al. 2006. Chem. Biol. 13: 957-963. PMID: 16984885

Estado de Materia :
Solid
Solubilidad :
Soluble in DMSO (100 mM), and ethanol (10 mM).
ALMACENAMIENTO :
Store at 4° C
Indice de Refracción :
n20D 1.76 (Predicted)
IC50 :
CDK1/Cyclin B: IC50 = 92.0 µM; GSK-3 α/β: IC50 = 44-100 µM; CDK5/p25: IC50 = >100 µM
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
PubChem CID :
SMILES :
CN1C2=C(C=CC(=C2)Br)/C(=C/3\\C(=C4C=CC=CC4=N3)NO)/C1=O

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

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Citaciones 1 a 1 de un total de 1

PMID: # 27009085  Ansari, S. et al. 2016. Ann Biomed Eng. 44: 1908-20.

Citaciones 1 a 1 de un total de 1
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