Integrin β5/ITGB5 Antibody (G-10): sc-515486

Integrin β5 Antibody (G-10) is a mouse monoclonal IgG3 antibody that detects Integrin β5 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin β5 is a crucial component of the integrin family, functioning as a receptor that mediates cell adhesion to the extracellular matrix and plays a significant role in various cellular processes. Integrin β5 is primarily located on the cell surface, where Integrin β5 forms heterodimers with integrin α subunits, facilitating interactions with ligands such as fibronectin and vitronectin. Proper localization of Integrin β5 is essential for function in cell signaling and adhesion, as Integrin β5 allows for the transduction of signals that influence cell behavior, including migration, proliferation, and survival. Furthermore, Integrin β5 is involved in the regulation of cellular responses to the extracellular environment, making Integrin β5 a vital player in tissue development and repair. Anti-Integrin β5 antibody (G-10) is an invaluable tool for researchers studying the dynamics of cell adhesion and signaling pathways in various biological contexts.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Integrin β5/ITGB5 Antibody (G-10) References:

1. Integrin-β1, not integrin-β5, mediates osteoblastic differentiation and ECM formation promoted by mechanical tensile strain.  |  Zeng, Q., et al. 2015. Biol Res. 48: 25. PMID: 25971622
2. Integrin β5 enhances the malignancy of human colorectal cancer by increasing the TGF-β signaling.  |  Shi, W., et al. 2021. Anticancer Drugs. 32: 717-726. PMID: 33587354
3. ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway.  |  Wen, X., et al. 2022. Front Oncol. 12: 887068. PMID: 36249018
4. Dichotomous role of integrin-β5 in lung endothelial cells.  |  Blanchard, N., et al. 2022. Pulm Circ. 12: e12156. PMID: 36438452
5. Upregulation of CSNK1A1 induced by ITGB5 confers to hepatocellular carcinoma resistance to sorafenib in vivo by disrupting the EPS15/EGFR complex.  |  Gu, L., et al. 2023. Pharmacol Res. 192: 106789. PMID: 37149115
6. Integrin β5 subunit regulates hyperglycemia-induced vascular endothelial cell apoptosis through FoxO1-mediated macroautophagy.  |  Lin, X., et al. 2024. Chin Med J (Engl). 137: 565-576. PMID: 37500497
7. ITGB5 facilitates gastric cancer metastasis by promoting TGFBR2 endosomal recycling.  |  Lei, T., et al. 2024. Cancer Lett. 592: 216953. PMID: 38729557
8. ROS-mediated ITGB5 promotes tongue squamous cell carcinoma metastasis through epithelial mesenchymal transition and cell adhesion signal pathway.  |  Chen, W., et al. 2024. J Cancer Res Clin Oncol. 150: 398. PMID: 39180583
9. Integrin β5, a noninvasive diagnostic biomarker, is associated with unfavorable prognosis and immunotherapy efficacy in gastric cancer.  |  Cheng, Y., et al. 2024. BMC Gastroenterol. 24: 362. PMID: 39394072
10. Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis.  |  Chan, XY., et al. 2024. Cell Mol Biol Lett. 29: 136. PMID: 39511483

The preferred Integrin β5/ITGB5 antibody is Integrin β5/ITGB5 Antibody (F-5): sc-398214.