Integrin β2/ITGB2/CD18 Antibody (GAME-46): sc-19624
- Integrin β2/ITGB2/CD18 Antibody (GAME-46) is a rat monoclonal IgG1, cited in 3 publications, provided at 200 µg/ml
- recommended for detection of Integrin β2 of mouse origin by IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for blocking, sc-19624 L, 200 µg/0.1 ml
- See Integrin β2/ITGB2/CD18 (CTB104): sc-8420 for Integrin β2/ITGB2/CD18 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Integrin β2/ITGB2/CD18 Antibody (GAME-46). This work is in progress.
QUICK LINKS
SEE ALSO...
Integrin β2 Antibody (GAME-46) is a rat monoclonal IgG1 antibody that detects Integrin β2 in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Integrin β2 is a crucial component of the integrin family, which consists of heterodimeric receptors that play a vital role in cell adhesion and signaling. Integrin β2 is primarily located on the cell surface, where anti-Integrin β2 antibody (GAME-46) can detect interactions with various ligands in the extracellular matrix, such as Fibronectin and Collagen, as well as with counterreceptors on adjacent cells. Integrin β2 presence on the cell membrane is essential for mediating cellular responses to the extracellular environment, influencing processes such as cell migration, immune response, and tissue repair. Additionally, Integrin β2 forms complexes with other integrin subunits, enhancing functional diversity and enabling participation in a wide range of biological activities. Integrin β2 (GAME-46) antibody helps researchers gain insights into the dynamic roles of Integrin β2 in various physiological and pathological contexts, making anti-Integrin β2 antibody (GAME-46) an invaluable tool for studies focused on cell adhesion and signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Integrin β2/ITGB2/CD18 Antibody (GAME-46) References:
- Integrin beta2-chain (CD18) over-expression on CD4+ T cells and monocytes after ischemia/reperfusion in patients undergoing primary percutaneous revascularization. | Sardella, G., et al. 2004. Int J Immunopathol Pharmacol. 17: 165-70. PMID: 15171817
- PRDM4 mediates YAP-induced cell invasion by activating leukocyte-specific integrin β2 expression. | Liu, H., et al. 2018. EMBO Rep. 19: PMID: 29669796
- The role of β2 integrin associated heparin-binding protein release in ARDS. | Liu, Y., et al. 2018. Life Sci. 203: 92-98. PMID: 29679701
- Coronin 1 Is Required for Integrin β2 Translocation in Platelets. | Riley, DRJ., et al. 2020. Int J Mol Sci. 21: PMID: 31948107
- [Effect of overexpression of integrin β2 on clinical prognosis in triple negative breast cancer]. | Puerkaiti, P., et al. 2020. Zhonghua Yi Xue Za Zhi. 100: 2358-2362. PMID: 32791811
- Molecular mechanisms of leukocyte β2 integrin activation. | Wen, L., et al. 2022. Blood. 139: 3480-3492. PMID: 35167661
- Structural Basis of β2 Integrin Inside-Out Activation. | Wen, L., et al. 2022. Cells. 11: PMID: 36231001
- Deletion of Cd44 Inhibits Metastasis Formation of Liver Cancer in Nf2-Mutant Mice. | Gerardo-Ramírez, M., et al. 2023. Cells. 12: PMID: 37174657
- Loss of β2-integrin function results in metabolic reprogramming of dendritic cells, leading to increased dendritic cell functionality and anti-tumor responses. | Harjunpää, H., et al. 2024. Oncoimmunology. 13: 2369373. PMID: 38915784
- The integrin beta subunit. | Green, LJ., et al. 1998. Int J Biochem Cell Biol. 30: 179-84. PMID: 9608671
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin β2/ITGB2/CD18 Antibody (GAME-46) | sc-19624 | 200 µg/ml | $322.00 | |||
Integrin β2/ITGB2/CD18 Antibody (GAME-46) FITC | sc-19624 FITC | 200 µg/ml | $336.00 | |||
Integrin β2/ITGB2/CD18 Antibody (GAME-46) L | sc-19624 L | 200 µg/0.1 ml | $322.00 | |||
Integrin β2/ITGB2/CD18 Antibody (GAME-46) PE | sc-19624 PE | 200 µg/ml | $349.00 |